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Meningeal Immunity, Drainage, and Tertiary Lymphoid Structure Formation

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Tertiary Lymphoid Structures

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1845))

Abstract

For decades, the brain has been considered an immune-privileged organ, meaning that the brain was mainly ignored by the immune system and that the presence of immune cells, notably of the adaptive arm, was a hallmark of pathological conditions. Over the past few decades, the definition of the immune privilege continues to be refined. There has been evidence accumulating that shows that the immune system plays a role in proper brain function. This evidence may represent an effective source of therapeutic targets for neurological disorders. In this chapter, we discuss the recent advances in understanding the immunity of the brain and describe how tertiary lymphoid structures can be generated in the central nervous system, which might represent a new avenue to treat neurological disorders.

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Acknowledgments

We would like to thank D. Preston for editing the manuscript and L. Louveau for the artwork.

Funding: This work was supported by LE&RN Postdoctoral Fellowship Award to A.L.

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  1. Center for Brain Immunology and Glia (BIG), Department of Neuroscience, University of Virginia, Charlottesville, VA, USA

    Antoine Louveau

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Correspondence to Antoine Louveau .

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  1. Laboratory “Cancer, Immune Control and Escape”, UMRS 1138 INSERM, Cordeliers Research Center, Sorbonne University, UMR 1138, Paris Descartes University, Sorbonne Paris City, UMR 1138, Paris, France

    Marie-Caroline Dieu-Nosjean

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Louveau, A. (2018). Meningeal Immunity, Drainage, and Tertiary Lymphoid Structure Formation. In: Dieu-Nosjean, MC. (eds) Tertiary Lymphoid Structures. Methods in Molecular Biology, vol 1845. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8709-2_3

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  • DOI: https://doi.org/10.1007/978-1-4939-8709-2_3

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-8708-5

  • Online ISBN: 978-1-4939-8709-2

  • eBook Packages: Springer Protocols

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