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The Ca2+-Binding S100B Protein: An Important Diagnostic and Prognostic Neurobiomarker in Pediatric Laboratory Medicine

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Calcium-Binding Proteins of the EF-Hand Superfamily

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1929))

Abstract

In recent decades a significant scientific effort has focused on projects regarding the use of neurobiomarkers in perinatal medicine with a view to understanding the mechanisms that interfere with physiological patterns of brain development and lead to ominous effects in several human diseases. Numerous potential neurobiomarkers have been proposed for use in monitoring high-risk fetuses and newborns, including markers of oxidative stress, neuroproteins, and vasoactive agents. Nonetheless, the use of these markers in clinical practice remains a matter of debate. Recently, the calcium-binding S100B protein has been proposed as being an ideal neurobiomarker, thanks to its simple availability and easy reproducibility, to the possibility of detecting it noninvasively in biological fluids with good reproducibility, and to the possibility of a longitudinal evaluation in relation to reference curves. The present chapter contains an overview of the most significant studies on the assessment of S100B in different biological fluids as a trophic factor and/or marker of brain damage in high-risk fetuses and newborns.

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Authors and Affiliations

  1. Neonatal Intensive Care Unit, Department of Pediatrics, University of Chieti, Chieti, Italy

    Diego Gazzolo, Giuseppe Lapergola & Simone Franchini

  2. Neonatal Intensive Care Unit, Department of Maternal, Fetal and Neonatal Medicine, C. Arrigo Children’s Hospital, Alessandria, Italy

    Diego Gazzolo

  3. Department of Pediatric Cardiac Surgery, IRCCS San Donato Milanese Hospital, Milan, Italy

    Francesca Pluchinotta

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  1. Diego Gazzolo
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  2. Francesca Pluchinotta
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  3. Giuseppe Lapergola
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  4. Simone Franchini
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Editors and Affiliations

  1. Division of Clinical Chemistry and Biochemistry, Department of Pediatrics, University of Zürich, Zürich, Switzerland

    Claus W. Heizmann

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Gazzolo, D., Pluchinotta, F., Lapergola, G., Franchini, S. (2019). The Ca2+-Binding S100B Protein: An Important Diagnostic and Prognostic Neurobiomarker in Pediatric Laboratory Medicine. In: Heizmann, C. (eds) Calcium-Binding Proteins of the EF-Hand Superfamily. Methods in Molecular Biology, vol 1929. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-9030-6_44

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  • DOI: https://doi.org/10.1007/978-1-4939-9030-6_44

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