Abstract
β-Arrestin function has largely been investigated in cell culture-based systems. Here we describe methods to investigate β-arrestin2 signaling in vivo by developing novel mouse models and viral methods to overexpress β-arrestin2 in the mouse brain. The methods and concepts described here are in the context of Parkinson’s disease (PD) and developing automated in vivo drug screening platforms.
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Acknowledgments
I would like to thank the Michael J. Fox Foundation (grant #11764) for their support in this project. I would also like to thank Dr. Marc Caron, in whose lab this work was conducted.
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Urs, N.M. (2019). Methods to Investigate the Role of β-Arrestin Signaling in Parkinson’s Disease. In: Scott, M., Laporte, S. (eds) Beta-Arrestins. Methods in Molecular Biology, vol 1957. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-9158-7_24
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DOI: https://doi.org/10.1007/978-1-4939-9158-7_24
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