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Preparation and Characterization of Micelles

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Pharmaceutical Nanotechnology

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2000))

Abstract

Nanoformulations in the past few decades have gained tremendous attention owing to their affirmative applications in increasing the bioavailability of poorly soluble drugs. Micelles in particular are favored due to their varied advantages which include thermodynamic stability, simple formulating steps, Newtonian flow, and enhanced biological barrier penetration. Owing to these advantages micellar nanosystems find extensive applications in oral, transdermal, and parenteral administration, and are now being explored for ocular and other noninvasive novel pathways of drug delivery such as nose to brain. In this chapter, we have discussed the protocol for the preparation of sumatriptan loaded micelles for the therapy of migraine. The inner core of these micelles comprises hydrophobic region of diblock polymer which holds the drug, while the hydrophilic region of the same provides conformational stability in the aqueous environment.

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Acknowledgments

The authors are thankful to the Board of Research in Nuclear Sciences (Sanction No. 2006/35/11/BRNS), Department of Atomic Energy, Govt. of India, for providing research funding. The authors are also thankful to Dr. Krishanu Ray and Mr. Lalit Borade from Tata Institute of Fundamental Research, Mumbai, Dr. P. Hassan and Dr. Vinod Aswal from Bhabha Atomic Research Centre, and Prof. Ishi Talmol, Haifa, Israel for their help towards successful completion of this project.

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai, India

    Vandana B. Patravale, Prashant G. Upadhaya & Ratnesh D. Jain

Authors
  1. Vandana B. Patravale
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  2. Prashant G. Upadhaya
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  3. Ratnesh D. Jain
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Corresponding author

Correspondence to Vandana B. Patravale .

Editor information

Editors and Affiliations

  1. Department of Pharmaceutical Sciences, College of Pharmacy, Midwestern University, Glendale, AZ, USA

    Volkmar Weissig

  2. Nanomedicine Center of Excellence in Translational Cancer Research, Midwestern University, Glendale, AZ, USA

    Tamer Elbayoumi

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Patravale, V.B., Upadhaya, P.G., Jain, R.D. (2019). Preparation and Characterization of Micelles. In: Weissig, V., Elbayoumi, T. (eds) Pharmaceutical Nanotechnology. Methods in Molecular Biology, vol 2000. Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9516-5_2

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  • DOI: https://doi.org/10.1007/978-1-4939-9516-5_2

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-4939-9515-8

  • Online ISBN: 978-1-4939-9516-5

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