Abstract
Binge drinking (BD), characterized by intermittent consumption of large quantities of alcohol in short periods of time, is the main alcohol consumption pattern in adolescents and young adults. BD has serious biomedical consequences, and it is a prominent risk factor for later development of alcohol use disorders. Rodent models offer exceptional power to study these negative consequences of BD. This chapter focuses on one of these BD models: the chronic-intermittent ethanol administration (CIEA) paradigm. Essentially, CIEA consists of the administration in rats or mice of i.p. injections of ethanol (doses: 3–4 g/kg) for several consecutive days each week, in alternation with several days without injections, during several weeks. Due to our interest in the neurobehavioral effects of BD, a combination of the CIEA model with a battery of behavioral tests is described, with emphasis on the effects of alcohol BD on different kinds of memory. The CIEA model, in combination with behavioral tasks, seems to be a useful tool for studying the neurobehavioral effects of BD as well as for developing potential prevention and treatment strategies.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Observatorio Español sobre Drogas (OED) (2016) Encuesta Escolar sobre Uso de Drogas en Estudiantes de Enseñanzas Secundarias (ESTUDES). Ministerio de Sanidad, Servicios Sociales e Igualdad, Madrid, pp 2014–2015
National Institute on Alcohol and Alcoholism (2004) NIAA council approves definition of binge drinking. Department of Health and Human Services. NIAA Newsletter 3:3
Courtney KE, Polich J (2009) Binge drinking in young adults: data, definitions, and determinants. Psychol Bull 135:142–156
Crabbe JC, Harris RA, Koob GF (2011) Preclinical studies of alcohol binge drinking. Ann N Y Acad Sci 1216:24–40
Kuntsche E, Kuntsche S, Thrul J, Gmel G (2017) Binge drinking: health impact, prevalence, correlates and interventions. Psychol Health 32:976–1017
Fritz BM, Boehm SL 2nd. (2016) Rodent models and mechanisms of voluntary binge-like ethanol consumption: examples, opportunities, and strategies for preclinical research. Prog Neuro-Psychopharmacol Biol Psychiatry 65:297–308
Sprow GM, Thiele TE (2012) The neurobiology of binge-like ethanol drinking: evidence from rodent models. Physiol Behav 106:325–331
Maldonado-Devincci AM, Badanich KA, Kirstein CL (2010) Alcohol during adolescence selectively alters immediate and long-term behavior and neurochemistry. Alcohol 44:57–66
Sanchez-Roige S, Peña-Oliver Y, Ripley TL, Stephens DN (2014) Repeated ethanol exposure during early and late adolescence: double dissociation of effects on waiting and choice impulsivity. Alcohol Clin Exp Res 38:2579–2589
Lacaille H, Duterte-Boucher D, Liot D, Vaudry H, Naasila M, Vaudry D (2015) Comparison of the deleterious effects of binge drinking-like alcohol exposure in adolescent and adult mice. J Neurochem 132:629–641
Broadwater M, Varlinskaya EI, Spear LP (2011) Chronic intermittent ethanol exposure in early adolescent and adult male rats: effects on tolerance, social behavior, and ethanol intake. Alcohol Clin Exp Res 35:1392–1403
Nogales F, Rua RM, Ojeda ML, Murillo ML, Carreras O (2014) Oral or intraperitoneal binge drinking and oxidative balance in adolescent rats. Chem Res Toxicol 27:1926–1933
Sánchez P, Castro B, Torres JM, Ortega E (2014) Effects of different ethanol-administration regimes on mRNA and protein levels of steroid 5α-reductase isozymes in prefrontal cortex of adolescent male rats. Psychopharmacology 231:3273–3280
Gold PE (1986) The use of avoidance training in studies of modulation of memory storage. Behav Neural Biol 46:87–98
Parra A, Rama E, Vinader-Caerols C, Monleón S (2013) Inhibitory avoidance in CD1 mice: sex matters, as does the supplier. Behav Process 100:36–39
Markwiese BJ, Acheson SK, Levin ED, Wilson WA, Swartzwelder HS (1998) Differential effects of ethanol on memory in adolescent and adult rats. Alcohol Clin Exp Res 22:416–421
Bell RL, Rodd ZA, Engleman EA, Toalston JE, McBride WJ (2014) Scheduled access alcohol drinking by alcohol-preferring (P) and high-alcohol-drinking (HAD) rats: modeling adolescent and adult binge-like drinking. Alcohol 48:225–234
Dutta S, Sengupta P (2016) Men and mice: relating their ages. Life Sci 152:244–248
Alfonso-Loeches S, Pascual M, Guerri C (2013) Gender differences in alcohol-induced neurotoxicity and brain damage. Toxicology 311:27–34
Vinader-Caerols C, Talk A, Montañés A, Duque A, Monleón S (2017) Differential effects of alcohol on memory performance in adolescent men and women with a binge drinking history. Alcohol Alcohol 52:610–616
Knapp DJ, Breese GR (2012) Models of chronic alcohol exposure and dependence. In: Kobeissy F (ed) Psychiatric disorders, Methods in molecular biology (methods and protocols), vol 829. Humana Press, New York, pp 205–230
Acknowledgments
This work was supported in part by PROMETEO-II/2015/020 from “Generalitat Valenciana” and UV-INV_AE18-779336 from “Universitat de València”, Spain.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Science+Business Media, LLC, part of Springer Nature
About this protocol
Cite this protocol
Monleón, S., Duque, A., Mesa-Gresa, P., Redolat, R., Vinader-Caerols, C. (2019). An Animal Model of Alcohol Binge Drinking: Chronic-Intermittent Ethanol Administration in Rodents. In: Kobeissy, F. (eds) Psychiatric Disorders. Methods in Molecular Biology, vol 2011. Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9554-7_16
Download citation
DOI: https://doi.org/10.1007/978-1-4939-9554-7_16
Published:
Publisher Name: Humana, New York, NY
Print ISBN: 978-1-4939-9553-0
Online ISBN: 978-1-4939-9554-7
eBook Packages: Springer Protocols