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The Post-transcriptional Operon

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RNA

Part of the book series: Methods in Molecular Biology ((MIMB,volume 703))

Abstract

A post-transcriptional operon is a set of monocistronic mRNAs encoding functionally related proteins that are co-regulated by a group of RNA-binding proteins and/or small non-coding RNAs so that protein expression is coordinated at the post-transcriptional level. The post-transcriptional operon model (PTO) is used to describe data from an assortment of methods (e.g. RIP-Chip, CLIP-Chip, miRNA profiling, ribosome profiling) that globally address the functionality of mRNA. Several examples of post-transcriptional operons have been documented in the literature and demonstrate the usefulness of the model in identifying new participants in cellular pathways as well as in deepening our understanding of cellular responses.

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Author information

Authors and Affiliations

  1. College of Nanoscale Science and Engineering, Nanoscale Constellation, University at Albany-SUNY, Rensselaer, NY, USA

    Scott A. Tenenbaum

  2. Department of Biology, University of Copenhagen, Copenhagen, Denmark

    Jan Christiansen

  3. Department of Cellular and Molecular Medicine, The Panum Institute, University of Copenhagen, Copenhagen, Denmark

    Henrik Nielsen

Authors
  1. Scott A. Tenenbaum
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  2. Jan Christiansen
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  3. Henrik Nielsen
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Corresponding author

Correspondence to Scott A. Tenenbaum .

Editor information

Editors and Affiliations

  1. The Panum Institute, Dept. of Cellular & Molecular Medicine, University of Copenhagen, Blegdamsvej 3, Copenhagen, 2200N, Denmark

    Henrik Nielsen

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Tenenbaum, S.A., Christiansen, J., Nielsen, H. (2011). The Post-transcriptional Operon. In: Nielsen, H. (eds) RNA. Methods in Molecular Biology, vol 703. Humana Press. https://doi.org/10.1007/978-1-59745-248-9_16

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  • DOI: https://doi.org/10.1007/978-1-59745-248-9_16

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-913-0

  • Online ISBN: 978-1-59745-248-9

  • eBook Packages: Springer Protocols

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