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Cancer Genome Analysis Informatics

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Genetic Variation

Part of the book series: Methods in Molecular Biology ((MIMB,volume 628))

Abstract

The analysis of cancer genomes has benefited from the advances in technology that enable data to be generated on an unprecedented scale, describing a tumour genome’s sequence and composition at increasingly high resolution and reducing cost. This progress is likely to increase further over the coming years as next-generation sequencing approaches are applied to the study of cancer genomes, in tandem with large-scale efforts such as the Cancer Genome Atlas and recently announced International Cancer Genome Consortium efforts to complement those already established such as the Sanger Institute Cancer Genome Project. This presents challenges for the cancer researcher and the research community in general, in terms of analysing the data generated in one’s own projects and also in coordinating and interrogating data that are publicly available. This review aims to provide a brief overview of some of the main informatics resources currently available and their use, and some of the informatics approaches that may be applied in the study of cancer genomes.

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Acknowledgements

The author would like to thank Dr. Pall Jonsson and Dr. Tim French for their helpful comments and suggestions during the preparation of this manuscript.

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Authors and Affiliations

  1. Cancer Bioscience, AstraZeneca, Macclesfield, Cheshire, UK

    Ian P. Barrett

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  1. Ian P. Barrett
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Correspondence to Ian P. Barrett .

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Editors and Affiliations

  1. Medicines Research Centre, GlaxoSmithKline R&D Limited, Gunnels Wood Road, Stevenage, Hertfordshire, SG12NY, United Kingdom

    Michael R. Barnes

  2. Institute of Psychiatry, Social, Genetic & Developmental, King's College, Denmark Hill 111, London, SE58AF, United Kingdom

    Gerome Breen

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Barrett, I.P. (2010). Cancer Genome Analysis Informatics. In: Barnes, M., Breen, G. (eds) Genetic Variation. Methods in Molecular Biology, vol 628. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60327-367-1_5

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  • DOI: https://doi.org/10.1007/978-1-60327-367-1_5

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-60327-366-4

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