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References
Markel P, Shu P, Ebeling C et al (1997) Theoretical and empirical issues for marker-assisted breeding of congenic mouse strains. Nat Genet 17:280–284
Smith JD, Bhasin JM, Baglione J et al (2006) Atherosclerosis susceptibility loci identified from a strain intercross of apolipoprotein E-deficient mice via a high-density genome scan. Arterioscler Thromb Vasc Biol 26:597–603
Lander ES, Green P, Abrahamson J et al (1987) MAPMAKER: an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations. Genomics 1:174–181
Manly KF, Cudmore RH, Jr, Meer JM (2001) Map Manager QTX, cross-platform software for genetic mapping. Mamm Genome 12:930–932
Broman KW, Wu H, Sen S, Churchill GA (2003) R/qtl: QTL mapping in experimental crosses. Bioinformatics 19:889–890
Broman KW (2001) Review of statistical methods for QTL mapping in experimental crosses. Lab Anim (NY) 30:44–52
Lander E, Kruglyak L (1995) Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 11:241–247
Churchill GA, Doerge RW (1994) Empirical threshold values for quantitative trait mapping. Genetics 138:963–971
Green EL (1966) in Biology of the Laboratory Mouse. McGraw-Hill, New York, N.Y.
Churchill GA, Airey DC, Allayee H et al (2004) The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat Genet 36: 1133–1137
Singer JB, Hill AE, Burrage LC et al (2004) Genetic dissection of complex traits with chromosome substitution strains of mice. Science 304:445–448
Davis RC, Schadt EE, Smith D J et al (2005) A genome-wide set of congenic mouse strains derived from DBA/2J on a C57BL/6J background. Genomics 86:259–270
Glazier AM, Nadeau JH, Aitman TJ (2002) Finding genes that underlie complex traits. Science 298:2345–2349
Abiola O, Angel JM, Avner P et al (2003) The nature and identification of quantitative trait loci: a community's view. Nat Rev Genet 4:911–916
Nord AS, Chang PJ, Conklin BR et al (2006) The International Gene Trap Consortium Website: a portal to all publicly available gene trap cell lines in mouse. Nucleic Acids Res 34:D642–D648
Kissler S, Stern P, Takahashi K et al (2006) In vivo RNA interference demonstrates a role for Nrampl in modifying susceptibility to type 1 diabetes. Nat. Genet 38:479–483
Aitman TJ, Glazier AM, Wallace CA et al (1999) Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats. Nat Genet 21:76–83
Trogan E, Choudhury R P, Dansky HM et al (2002) Laser capture microdissection analysis of gene expression in macrophages from atherosclerotic lesions of apoli-poprotein E-deficient mice. Proc Natl Acad Sci U. S. A 99:2234–2239
Schadt EE, Monks SA, Drake TA et al (2003) Genetics of gene expression surveyed in maize, mouse and man. Nature 422:297–302
Brem RB, Yvert G, Clinton R, Kruglyak L (2002) Genetic dissection of transcriptional regulation in budding yeast. Science 296:752–755
Hubner N, Wallace CA, Zimdahl H et al (2005) Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease. Nat Genet 37:243–353
Kroymann J, Mitchell-Olds T (2005) Epistasis and balanced polymorphism influencing complex trait variation. Nature 435:95–98
Vitt U, Gietzen D, Stevens K et al (2004) Identification of candidate disease genes by EST alignments, synteny, and expression and verification of Ensembl genes on rat chromosome 1q43–54. Genome Res 14:640–50
Wang X, Ishimori N, Korstanje R et al (2005) Identifying novel genes for atherosclerosis through mouse-human comparative genetics. Am J Hum Genet 77:1–15
Stoll M, Kwitek-Black AE, Cowley AW, Jr et al (2000) New target regions for human hypertension via comparative genomics. Genome Res. 10:473–82
Wang X, Ria M, Kelmenson PM et al (2005) Positional identification of TNFSF4, encoding OX40 ligand, as a gene that influences atherosclerosis susceptibility. Nat Genet 37:365–372
Mehrabian M, Allayee H, Wong J et al (2002) Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice. Circ Res 91:120–126
Helgadottir A, Manolescu A, Thorleifsson G et al (2004) The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. Nat Genet 36:233–239
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Smith, J.D. (2008). Quantitative Trait Locus Mapping to Identify Genes for Complex Traits in Mice. In: Walker, J.M., Rapley, R. (eds) Molecular Biomethods Handbook. Springer Protocols Handbooks. Humana Press. https://doi.org/10.1007/978-1-60327-375-6_18
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DOI: https://doi.org/10.1007/978-1-60327-375-6_18
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