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Nonprimate Models for Glaucoma Retinopathy and Optic Neuropathy

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Animal Models for Retinal Diseases

Part of the book series: Neuromethods ((NM,volume 46))

Abstract

The generation and advancement of animal models have contributed significantly to the advancement of glaucoma research. This chapter describes and summarizes major nonprimate animal models useful for the study of this disease. Rodent models, both rats and mice, have been popular for glaucoma studies, because of the relatively better-developed genetic and genomic tools and the similarity of the relevant ocular structures between human and these animals. The larger animals, e.g., rabbit, feline, canine, bovine, ovine, and porcine models, have also been successfully used and provided valuable information on various aspects of the disease. Some of the models depicted in this chapter involve a transient or chronic ocular hypertension. Others do not affect intraocular pressure, but instead address certain specific mechanisms of the disease and serve as surrogate models.

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Authors and Affiliations

  1. Glaucoma Research, Alcon Research, Ltd, Fort Worth, TX, USA

    Iok-Hou Pang

  2. The North Texas Eye Research Institute and Department of Cell Biology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX, USA

    Abbot F. Clark

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  1. Iok-Hou Pang
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    Iok-Hou Pang

  2. Health Science Center, University of North Texas, Camp Bowie Blvd. 500, Fort Worth, 76107, U.S.A.

    Abbot F. Clark

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Pang, IH., Clark, A.F. (2010). Nonprimate Models for Glaucoma Retinopathy and Optic Neuropathy. In: Pang, IH., Clark, A. (eds) Animal Models for Retinal Diseases. Neuromethods, vol 46. Humana Press. https://doi.org/10.1007/978-1-60761-541-5_8

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