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An In Vitro System for Measuring the Transdermal Voltage and Molecular Flux Across the Skin in Real Time

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Electrochemotherapy, Electrogenetherapy, and Transdermal Drug Delivery

Part of the book series: Methods in Molecular Medicine ((MIMM,volume 37))

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Abstract

In many in vitro transdermal drug delivery experiments, the skin is placed within a permeation chamber, and measurements are taken every hour or so. However, during skin electroporation, significant molecular transport can occur within the first few minutes (1).

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References

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Author information

Authors and Affiliations

  1. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA

    Tani Chen & Robert Langer

  2. Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA

    Robert Langer

  3. Department of Chemical Engineering, Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA

    James C. Weaver

Authors
  1. Tani Chen
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  2. Robert Langer
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  3. James C. Weaver
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Editor information

Editors and Affiliations

  1. University of South Florida College of Medicine, USA

    Mark J. Jaroszeski PhD  & Richard Heller PhD  & 

  2. University of South Florida College of Engineering, USA

    Richard Gilbert PhD

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© 2000 Humana Press Inc.

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Chen, T., Langer, R., Weaver, J.C. (2000). An In Vitro System for Measuring the Transdermal Voltage and Molecular Flux Across the Skin in Real Time. In: Jaroszeski, M.J., Heller, R., Gilbert, R. (eds) Electrochemotherapy, Electrogenetherapy, and Transdermal Drug Delivery. Methods in Molecular Medicine, vol 37. Humana Press. https://doi.org/10.1385/1-59259-080-2:407

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  • DOI: https://doi.org/10.1385/1-59259-080-2:407

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-606-2

  • Online ISBN: 978-1-59259-080-3

  • eBook Packages: Springer Protocols

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