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In Vitro Delivery of Drugs and Other Molecules to Cells

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Electrochemotherapy, Electrogenetherapy, and Transdermal Drug Delivery

Part of the book series: Methods in Molecular Medicine ((MIMM,volume 37))

Abstract

The permeability of a cell membrane can be transiently increased locally when an external electric field pulse with an overcritical intensity is applied. A position dependent modulation of the membrane potential difference is induced during the pulse. A local membrane alteration is created, which may reseal. Its molecular definition remains unknown. This phenomenon is now commonly known as electroporation or electropermeabilization. The former term implies that physical pores are created in the lipid matrix. However their existence has never been clearly demonstrated. The term electroporation is therefore rather misleading.

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Authors and Affiliations

  1. IPBS-CNRS UPR 9062, Toulouse, France

    Marie-Pierre Rols, Muriel Golzio, Christine Delteil & Justin Teissié

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  1. Marie-Pierre Rols
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  2. Muriel Golzio
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  3. Christine Delteil
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  4. Justin Teissié
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Editors and Affiliations

  1. University of South Florida College of Medicine, USA

    Mark J. Jaroszeski PhD  & Richard Heller PhD  & 

  2. University of South Florida College of Engineering, USA

    Richard Gilbert PhD

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© 2000 Humana Press Inc., Totowa, NJ

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Rols, MP., Golzio, M., Delteil, C., Teissié, J. (2000). In Vitro Delivery of Drugs and Other Molecules to Cells. In: Jaroszeski, M.J., Heller, R., Gilbert, R. (eds) Electrochemotherapy, Electrogenetherapy, and Transdermal Drug Delivery. Methods in Molecular Medicine, vol 37. Humana Press. https://doi.org/10.1385/1-59259-080-2:83

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  • DOI: https://doi.org/10.1385/1-59259-080-2:83

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-606-2

  • Online ISBN: 978-1-59259-080-3

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