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Oncolytic Adenoviral Vectors

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Gene Therapy of Cancer

Part of the book series: Methods in Molecular Medicine™ ((MIMM,volume 35))

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Abstract

It is important to analyze to what extent these random or designed mutations abrogate viral replication in normal cells because a tightly controlled vector could be injected at higher doses intratumorally or even systemically. On the other hand, it is also important to analyze to what extent these mutations affect the amount of virus produced per infected tumor cell (burst size) compared to wild-type virus because lower yields will result in a slower propagation throughout the tumor. Finally, as concluded from the clinical trials with wildtype

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Author information

Authors and Affiliations

  1. Wallace Tumor Institute, Department of Medicine-Pulmonary and Critical Care, University of Alabama, Birmingham, AL

    Ramon Alemany

  2. GenStar Therapeutics, San Diego, CA

    Wei-Wei Zhang

Authors
  1. Ramon Alemany
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  2. Wei-Wei Zhang
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Editor information

Editors and Affiliations

  1. Max-Delbrück-Center for Molecular Medicine, Berlin, Germany

    Wolfgang Walther  & Ulrike Stein  & 

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© 2000 Humana Press Inc., Totowa, NJ

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Alemany, R., Zhang, WW. (2000). Oncolytic Adenoviral Vectors. In: Walther, W., Stein, U. (eds) Gene Therapy of Cancer. Methods in Molecular Medicine™, vol 35. Humana Press. https://doi.org/10.1385/1-59259-086-1:395

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  • DOI: https://doi.org/10.1385/1-59259-086-1:395

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-714-4

  • Online ISBN: 978-1-59259-086-5

  • eBook Packages: Springer Protocols

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