Abstract
The hematopoietic growth factor granulocyte colony-stimulating factor (G-CSF) has been in the clinic since 1986, when the clinical development of bacterially synthesized recombinant filgrastim began (1). A glycosylated form of G-CSF (lenograstim) has been approved for use in Europe and a bacterial recombinant mutein (nartograstim) has been approved in Japan. All forms of G-CSF are now commonly used for many types of neutropenia, including that resulting from anticancer therapies.
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© 2004 Humana Press Inc., Totowa, NJ
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Eliason, J.F., Tare, N., Bowen, S., Inoue, T., Horii, I. (2004). In Vitro and In Vivo Assays for High-Molecular-Weight Pegylated Muteins of Granulocyte Colony-Stimulating Factor. In: De Ley, M. (eds) Cytokine Protocols. Methods in Molecular Biology, vol 249. Humana Press. https://doi.org/10.1385/1-59259-667-3:167
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DOI: https://doi.org/10.1385/1-59259-667-3:167
Publisher Name: Humana Press
Print ISBN: 978-0-89603-948-3
Online ISBN: 978-1-59259-667-6
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