Abstract:
Burden of disease assessments must incorporate both years of life lost and years lost to disability. This is especially important for diseases that have long-term effects in addition to early life mortality. Such is increasingly recognized to be the case for early childhood diarrhea, especially in impoverished areas. Although dramatic improvements have been made in reducing childhood diarrhea mortality, the morbidity (illness) rates persist, and have likely lasting effects on children’s physical and even cognitive development. Hence, even though data are limited, existing evidence suggests that these long-term effects of early childhood diarrhea on child development and thus cause potentially lifelong “disability” may be substantial. Although several approaches have been used to assess these disability and mortality impacts, including “Quality adjusted life years” and “Disability adjusted life years,” the latter (DALYs) have gained widespread use. We review this evidence and provide a range of estimates from published information on the “DALY impact” of early childhood diarrhea.
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Abbreviations
- ApoE4:
-
apolipoprotein E4
- CAT-1:
-
cationic arginine transporter 1
- DALY:
-
disability-adjusted life years
- EAEC:
-
enteroaggregative Escherichia coli
- ECD:
-
early childhood diarrhea
- HAART:
-
highly active antiretroviral therapy
- HAZ:
-
height-for-age z scores
- HIV:
-
human immunodeficiency virus
- HST:
-
Harvard step test
- IL-8:
-
interleukin-8
- IQ:
-
intelligence quotient
- ORNT:
-
oral rehydration and nutrition therapy
- ORT:
-
oral rehydration therapy
- QALY:
-
quality-adjusted life years
- SD:
-
standard deviation
- TB:
-
tuberculosis
- TONI III:
-
test of nonverbal intelligence, version III
- WISC:
-
Wechsler intelligence scale for children
- YLD:
-
years lost to disability
- YPLL:
-
years of potential life lost
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Oria, R., Pinkerton, R., Lima, A.A.M., Guerrant, R.L. (2010). DALYs and Diarrhea. In: Preedy, V.R., Watson, R.R. (eds) Handbook of Disease Burdens and Quality of Life Measures. Springer, New York, NY. https://doi.org/10.1007/978-0-387-78665-0_69
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DOI: https://doi.org/10.1007/978-0-387-78665-0_69
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