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TRAF6

  • Reference work entry
Encyclopedia of Signaling Molecules

Synonyms

E3 ubiquitin-protein ligase, tumor necrosis factor receptor-associated factor 6 (TRAF6); Interleukin-1 signal transducer; Location chromosome 11p12; MGC:3310; RING finger protein 85 (RNF85)

Historical Background

TRAF Family

Tumor necrosis factor receptor-associated factors 1 and 2 (TRAFs) were initially identified as adaptor proteins that associate with the type-2 tumor necrosis factor (TNF) receptor (TNF-R2) (Cao et al. 1996; Ishida et al. 1996; Rothe et al. 1994). The TRAF family members play important roles in the signal transduction cascades that regulate inflammatory responses via nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and mitogen-activated protein kinases (MAPKs) that are initiated by activated cell surface receptors, such as TNF-R, interleukin 1 receptor (IL-1R), and Toll-like receptors (TLRs). The TRAFs have different cellular and physiological functions despite of their conserved C-terminal domain found in TRAF1-6 (Fig. 1). Unlike the...

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Authors and Affiliations

  1. Department of Medical Biosciences, Department of Pathology, Umeå University, Building 6M, Hospithal area, Umeå, SE-901 85, Umeå, Sweden

    Prof. Maréne Landström & Reshma Sundar

  2. Ludwig Institute for Cancer Research, Uppsala University, SE-751 24, Uppsala, Sweden

    Prof. Maréne Landström

Authors
  1. Prof. Maréne Landström
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  2. Reshma Sundar
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Corresponding author

Correspondence to Maréne Landström .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Landström, M., Sundar, R. (2012). TRAF6. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0461-4_635

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