Synopsis
This entry will discuss:
The way in which sodium, potassium, and calcium ions move across membranes and within cells to facilitate important cellular processes
The role of magnesium in catalytic RNA
The numerous proteins and enzymes that contain porphyrin cofactors
Iron–sulfur clusters, important in biological redox chemistry
The role of some metalloenzymes that facilitate or moderate the reactions of dioxygen (O2), peroxide (O22−), and superoxide (O2−·)
Efforts by bioinorganic chemists to synthesize small molecules that model the biological activity of proteins and enzymes
The toxicity of certain inorganic species in biological systems
Metals used in medical applications
See Crichton (2008), Bertini et al. (2007), and Roat-Malone (2007).
Introduction
Bioinorganic chemistry studies the role of inorganic species in biological compounds. In this regard, proteins, enzymes, DNA, and RNA are the...
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Arano Y (2002) Recent advances in 99mTc radiopharmaceuticals. Ann Nucl Med 16(2):79–93
Berners-Price SJ, Filipovska A (2011) Gold compounds as therapeutic agents for human diseases. Metallomics 3(9):863–873
Bertini I, Gray HB, Stiefel EI, Valentine JS (2007) Biological inorganic chemistry. University Science, California
CATH. http://www.cathdb.info. Accessed 27 May 2014; and Pfam. http://pfam.xfam.org). Accessed 27 May 2014
Chang TMS (2007) Artificial cells: biotechnology, nanomedicine, regenerative medicine, blood substitutes, bioencapsulation, and cell/stem cell therapy. World Scientific, Singapore/London/Hackensack
Crichton R (2008) Biological inorganic chemistry: an introduction. Elsevier BV, Amsterdam
Denisov IG, Makris TM, Sligar SG, Schlichting I (2005) Structure and chemistry of cytochrome P450. Chem Rev 105:2253–2278
Groves JT, Bell SR (2009) A highly reactive P450 model compound. J Am Chem Soc 131(28):9640–9641
Hatcher LQ, Vance MA, Narducci Sargeant AA, Solomon EI, Karlin KD (2006) Copper-dioxygen adducts. Inorg Chem 45:3004–3013
Hengstler JG, Bolt HM (2008) A special issue on metal toxicity. Arch Toxicol 82(8):489–571
Howard JB, Rees DC (2006) How many metals does it take to fix N2? Proc Natl Acad Sci 103:17088–17093
Jena Library of Biological Molecules. http://www.fli-leibniz.de/IMAGE.html. Accessed 27 May 2014
Kim E, Chufan EE, Kallappan K, Karlin KK (2004) Synthetic Models for Heme-Copper Oxidases. Chem Rev 104:1077–1133
Lancaster CRD (2004) Structural biology: ion pump in the movies. Nature 432:286–287
Leitch JM, Yick PJ, Culotta VC (2009) The right to choose: multiple pathways for activating copper, zinc superoxide dismutase. J Biol Chem 284(37):24679–24683
Momenteau M, Reed CA (1994) Synthetic heme dioxygen complexes. Chem Rev 94:659–698
Nomenclature of the potassium channel superfamily. https://www.ipmc.cnrs.fr/~duprat/ipmc/nomenclature.html. Accessed 27 May 2014
Perry JJP, Shin DS, Getzoff ED, Tainer JA (2010) The structural biochemistry of the superoxide dismutases. Biochim Biophys Acta 1804(2):245–262
Pickett C, Best S (2005) Hydrogenases. Coord Chem Rev 249(15–16):1517–1690
Pratt AJ, Getzoff ED, Perry JJP (2012) Amyotrophic lateral sclerosis: update and new developments. Degener Neurol Neuromuscul Dis 2012(2):1–14
Protein Data Bank. www.pdb.org. Accessed 27 May 2014
Roat-Malone RM (2007) Bioinorganic chemistry. Wiley, New Jersey
Schrock RR, Yandulov DV (2003) Catalytic reduction of dinitrogen to ammonia at a single molybdenum center. Science 301:76–78
Structural Classification of Proteins (SCOP). http://scop.mrc-lmb.cam.ac.uk/scop/. Accessed 27 May 2014
Wang X, Guo Z (2013) Targeting and delivery of platinum-based anticancer drugs. Chem Soc Rev 42:202–224
Yu FH, Yarov-Yarovoy V, Gutman GA, Catterall WA (2005) Overview of molecular relationships in the voltage-gated ion channel superfamily. Pharmacol Rev 57:387–395
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer Science+Business Media, LLC
About this entry
Cite this entry
Roat-Malone, R. (2018). Bioinorganic Chemistry. In: Wells, R.D., Bond, J.S., Klinman, J., Masters, B.S.S. (eds) Molecular Life Sciences. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1531-2_407
Download citation
DOI: https://doi.org/10.1007/978-1-4614-1531-2_407
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4614-1529-9
Online ISBN: 978-1-4614-1531-2
eBook Packages: Biomedical and Life SciencesReference Module Biomedical and Life Sciences