Definition
The peptide hormone gastrin was originally identified as a stimulant of acid secretion, but is now known to also act as a growth factor in the gastrointestinal tract (Dockray et al. 2001). Gastrin is synthesized as a precursor of 101 amino acids (preprogastrin) which, on removal of the signal peptide of 21 amino acids, yields progastrin (80 amino acids). Proteolytic processing in antral G cells in the stomach generates a number of intermediate peptides, including glycine-extended gastrin 17 (Ggly), which has the sequence ZGPWLEEEEEAYGWMDFG. Transamidation of the C-terminal glycine yields the C-terminal amidated phenylalanine characteristic of amidated gastrin (Gamide). Both Ggly and Gamide are independently active, via different receptors, in the gastrointestinal tract.
Basic Characteristics
Iron: Interaction with Gastrin
Fluorescence experiments have revealed that both Ggly and Gamide bind two ferric ions with high affinity (K d= 0.6 μM, pH 4.0) in aqueous solution...
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References
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Baldwin, G.S. (2013). Bismuth, Interaction with Gastrin. In: Kretsinger, R.H., Uversky, V.N., Permyakov, E.A. (eds) Encyclopedia of Metalloproteins. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1533-6_200004
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DOI: https://doi.org/10.1007/978-1-4614-1533-6_200004
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