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The Research Domain Criteria (RDoC) project was initiated by the National Institute of Mental Health in 2009 to develop a novel classification of psychopathology. It represents a framework that explicates genes, brain, and behavior dimensions across heterogeneous categories of mental disorders (Insel and Wang 2010). As opposed to the symptom-based, categorical approach used to diagnose mental health conditions, the RDoC framework considers psychopathology based on disorders of brain circuits using genetics and neuroscience research tools to discover the biosignatures that can inform diagnoses and treatment of mental illness. The RDoC constructs are organized in a matrix containing five primary domains: negative valence, positive valence, cognitive systems, social processes, and arousal/regulatory systems. Each domain includes constituent constructs and seven units of analysis (e.g., genes, circuits, behavior).
The RDoC...
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Ibrahim, K., Sukhodolsky, D.G. (2018). RDoC and Autism. In: Volkmar, F. (eds) Encyclopedia of Autism Spectrum Disorders. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6435-8_102261-1
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DOI: https://doi.org/10.1007/978-1-4614-6435-8_102261-1
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