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Krüppel-Like Factor 4 (KLF4)

  • Living reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

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Synonyms

Epithelial zinc-finger; EZF; GKLF; Gut-enriched Krüppel-like factor; KLF4

Historical Background

The Krüppel-like factor (KLF) family is a subclass of zinc-finger containing DNA-binding transcription factors. There are currently 17 known KLF family members in mammals. The unique feature of the KLF family members is the presence of three highly conserved cysteine2/histidine2 (C2H2)-type zinc fingers at the carboxyl terminus of the protein, while other regions are highly divergent to carry out their individual functions (Fig. 1). KLF4 is one of the most attractive factors in the KLF family members, because it is implicated in multiple important processes including cellular proliferation, differentiation, and the establishment of pluripotency. KLF4 was first identified from a murine NIH/3T3 fibroblast cDNA library (Shields et al. 1996). Because it was expressed most abundantly in the colon, followed by the testis, lung, and small intestine, KLF4 was initially named as...

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References

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Authors and Affiliations

  1. Apheresis and Dialysis Center, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan

    Tadashi Yoshida

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  1. Tadashi Yoshida
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Correspondence to Tadashi Yoshida .

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Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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Yoshida, T. (2016). Krüppel-Like Factor 4 (KLF4). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101673-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_101673-1

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  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-6438-9

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