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CD44

  • Living reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

  • 131 Accesses

Synonyms

Cluster of differentiation 44; Cspg8 (Chondroitin sulfate proteoglycans 8); ECMR-III (Extracellular matrix receptor-III); HCELL (hematopoietic cell E-/L-selectin ligand); Homing cell adhesion molecule (HCAM); MDU2; MIC4; Phagocytic glycoprotein -1(Pgp-1)

Historical Background

CD44 is a transmembrane glycoprotein and also major hyaluronan receptor, mediating cell responses to the extracellular microenvironment. In 1980s, it was first described as a surface molecule restricted to few immune cells like lymphocytes, thymocytes, and granulocytes (Dalchau et al. 1980), but later it was recognized as a novel human erythrocyte cell surface antigen, lymphocyte homing receptor, and leukocyte surface glycoprotein (Stefanová et al. 1989). Today, CD44 is being described as an adhesion molecule expressed in various cell types which includes both epithelial cells (even in keratinocytes) and connective tissue cells (endothelial cells, fibroblasts and leukocytes). It participates in a number...

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References

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Author information

Authors and Affiliations

  1. MGM Dental College and Hospital, Navi Mumbai, Maharashtra, India

    Niharika Swain

  2. Institute of Dental Sciences, Siksha ‘O’ Anusandhan University, Bhubaneswar, 751003, Odisha, India

    Samapika Routray

  3. Indian Association of Oral and Maxillofacial Pathologists, Andheri, Mumbai, 76, Maharashtra, India

    Rashmi Maruti Hosalkar

Authors
  1. Niharika Swain
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  2. Samapika Routray
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  3. Rashmi Maruti Hosalkar
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Corresponding author

Correspondence to Niharika Swain .

Editor information

Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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Swain, N., Routray, S., Hosalkar, R.M. (2017). CD44. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101999-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_101999-1

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-6438-9

  • Online ISBN: 978-1-4614-6438-9

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