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A-Kinase Anchoring Protein (AKAP)

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Encyclopedia of Signaling Molecules

Synonyms

Protein kinase A (PKA, PRKA); A-kinase anchoring protein (AKAP); AKAP

Historical Background

Classical physiological experiments identified cAMP as a diffusible intracellular secondary messenger capable of activating cAMP-dependent protein kinase (PKA). These studies defined hormone- and location-specific patterns of PKA activation, suggesting that PKA signaling was compartmentalized. For example, in perfused rat cardiomyocytes, adrenergic stimulation selectively activates a pool of PKA isolated from certain fractions, while prostanoids predominately activate cytosolic PKA (Scott et al. 2013).

The first AKAP to be identified, microtubule-associated protein 2 (MAP2), was copurified with the PKA regulatory subunit subtype II (RII) from rat brain extracts. Over 50 additional AKAP family members have subsequently been identified (Fraser and Scott 1999; Scott et al. 2013). AKAPs are structurally diverse and share little primary sequence similarity, but are functionally similar and...

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References

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Acknowledgments

This work was supported by the following grants from the National Institutes of Health: 5R01DK105542 (J.D.S.) and 4P01DK05441 (J.D.S.).

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Authors and Affiliations

  1. Department of Pharmacology, Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA

    Laura Gabrovsek, Paula Bucko & John D. Scott

  2. Department of Pharmacology, University of Illinois at Chicago, 835 S. Wolcott Ave., E403 MSB, Chicago, IL, 60612, USA

    Graeme K. Carnegie

Authors
  1. Laura Gabrovsek
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  2. Paula Bucko
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  3. Graeme K. Carnegie
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  4. John D. Scott
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Corresponding author

Correspondence to John D. Scott .

Editor information

Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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Gabrovsek, L., Bucko, P., Carnegie, G.K., Scott, J.D. (2016). A-Kinase Anchoring Protein (AKAP). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_218-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_218-1

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  • Print ISBN: 978-1-4614-6438-9

  • Online ISBN: 978-1-4614-6438-9

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