Skip to main content
SpringerLink
Log in

Arl8b

  • Living reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

  • 54 Accesses

Synonyms

Adp-ribosylation factor-like 10C; ADP-ribosylation factor-like 8B; Arf-like protein 8B; Arl10c; Gie1; Small G protein indispensable for equal chromosome segregation 1

Historical Background

Arf (ADP-ribosylation factor) proteins were first discovered as membrane-bound cofactors in the cholera-toxin-dependent ADP-ribosylation of Gα (Kahn and Gilman 1984). They are a family of Ras-related small GTP-binding proteins, approximately 21 kDa in size, and are expressed abundantly in all eukaryotic cells and some bacteria (Quinn 1995; Dong et al. 2007). Arfs regulate membrane trafficking and actin cytoskeleton dynamics, which are important for cellular events such as endocytosis, cell secretion, cell adhesion, cell migration, and neurite outgrowth (D’Souza-Schorey and Chavrier 2006). They act as molecular switches for many cellular pathways by cycling between inactive GDP-binding and active GTP-binding forms. Arf proteins are activated by guanine-nucleotide exchange factors (GEFs) and...

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

References

  • Bagshaw RD, Callahan JW, Mahuran DJ. The Arf-family protein, Arl8b, is involved in the spatial distribution of lysosomes. Biochem Biophys Res Commun. 2006;344:1186–91. doi:10.1016/j.bbrc.2006.03.221.

    Article  CAS  PubMed  Google Scholar 

  • Bagshaw RD, Mahuran DJ, Callahan JW. A proteomic analysis of lysosomal integral membrane proteins reveals the diverse composition of the organelle. Mol Cell Proteomics. 2005;4:133–43. doi:M400128–MCP200 [pii]10.1074/mcp.M400128-MCP200

    Article  CAS  PubMed  Google Scholar 

  • D'Souza-Schorey C, Chavrier P. ARF proteins: roles in membrane traffic and beyond. Nat Rev Mol Cell Biol. 2006;7:347–58.

    Article  PubMed  Google Scholar 

  • Donaldson JG, Honda A. Localization and function of Arf family GTPases. Biochem Soc Trans. 2005;33:639–42. doi:BST0330639 [pii]10.1042/BST0330639

    Article  CAS  PubMed  Google Scholar 

  • Donaldson JG, Jackson CL. ARF family G proteins and their regulators: roles in membrane transport, development and disease. Nat Rev Mol Cell Biol. 2011;12:362–75.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dong JH, Wen JF, Tian HF. Homologs of eukaryotic Ras superfamily proteins in prokaryotes and their novel phylogenetic correlation with their eukaryotic analogs. Gene. 2007;396:116–24. doi:10.1016/j.gene.2007.03.001.

    Article  CAS  PubMed  Google Scholar 

  • Dykes SS, Gray AL, Coleman DT, Saxena M, Stephens CA, Carroll JL, et al. The Arf-like GTPase Arl8b is essential for three-dimensional invasive growth of prostate cancer in vitro and xenograft formation and growth in vivo. Oncotarget. 2016;7:31037–52.

    PubMed  PubMed Central  Google Scholar 

  • Garin J, Diez R, Kieffer S, Dermine JF, Duclos S, Gagnon E, et al. The phagosome proteome: Insight into phagosome functions. J Cell Biol. 2001;152:165–80. doi:10.1083/jcb.152.1.165.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gillingham AK, Munro S. The small G proteins of the Arf family and their regulators. Annu Rev Cell Dev Biol. 2007;23:579–611.

    Article  CAS  PubMed  Google Scholar 

  • Gillingham AK, Sinka R, Torres IL, Lilley KS, Munro S. Toward a comprehensive map of the effectors of rab GTPases. Dev Cell. 2014;31:358–73. doi:10.1016/j.devcel.2014.10.007S1534-5807(14)00653-4. [pii]

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Haraguchi T, Yanaka N, Nogusa Y, Sumiyoshi N, Eguchi Y, Kato N. Expression of ADP-ribosylation factor-like protein 8B mRNA in the brain is down-regulated in mice fed a high-fat diet. Biosci Biotechnol Biochem. 2006;70:1798–802. doi:10.1271/bbb.60168.

    Article  CAS  PubMed  Google Scholar 

  • Hofmann I, Munro S. An N-terminally acetylated Arf-like GTPase is localised to lysosomes and affects their motility. J Cell Sci. 2006;119:1494–503.

    Article  CAS  PubMed  Google Scholar 

  • Hong JX. Phospholipid- and GTP-dependent activation of cholera toxin and phospholipase D by human ADP-ribosylation factor-like protein 1 (HARL1). J Biol Chem. 1998;273:15872–6.

    Article  CAS  PubMed  Google Scholar 

  • Ishida M, Ohbayashi N, Fukuda M. Rab1A regulates anterograde melanosome transport by recruiting kinesin-1 to melanosomes through interaction with SKIP. Sci Report. 2015;5:8238. doi:10.1038/srep08238.

    Article  CAS  Google Scholar 

  • Kahn RA, Cherfils J, Elias M, Lovering RC, Munro S, Schurmann A. Nomenclature for the human Arf family of GTP-binding proteins: ARF, ARL, and SAR proteins. J Cell Biol. 2006;172:645–50. doi:10.1083/jcb.200512057.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kahn RA, Gilman AG. Purification of a protein cofactor required for adp-ribosylation of the stimulatory regulatory component of adenylate-cyclase by cholera-toxin. J Biol Chem. 1984;259:6228–34.

    CAS  PubMed  Google Scholar 

  • Kahn RA, Volpicelli-Daley L, Bowzard B, Shrivastava-Ranjan P, Li Y, Zhou C, et al. Arf family GTPases: roles in membrane traffic and microtubule dynamics. Biochem Soc T. 2005;33:1269–72.

    Article  CAS  Google Scholar 

  • Khatter D, Raina VB, Dwivedi D, Sindhwani A, Bahl S, Sharma M. The small GTPase Arl8b regulates assembly of the mammalian HOPS complex on lysosomes. J Cell Sci. 2015;128:1746–61. doi:10.1242/jcs.162651. [pii]

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Klassen MP. An Arf-like small G protein, ARL-8, promotes the axonal transport of presynaptic cargoes by suppressing vesicle aggregation. Neuron. 2010;66:710–23.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Klassen MP, Wu YE, Maeder CI, Nakae I, Cueva JG, Lehrman EK, et al. An Arf-like small G protein, ARL-8, promotes the axonal transport of presynaptic cargoes by suppressing vesicle aggregation. Neuron. 2010;66:710–23. doi:10.1016/j.neuron.2010.04.033.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Korolchuk VI, Saiki S, Lichtenberg M, Siddiqi FH, Roberts EA, Imarisio S, et al. Lysosomal positioning coordinates cellular nutrient responses. Nat Cell Biol. 2011;13:453–U242. doi:10.1038/ncb2204.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kwon MJ, Oh E, Lee S, Roh MR, Kim SE, Lee Y, et al. Identification of novel reference genes using multiplatform expression data and their validation for quantitative gene expression analysis. PLoS One. 2009;4. doi:ARTN e6162231371/journal.pone.0006162.

    Google Scholar 

  • Li YW, Kelly WG, Logsdon JM, Schurko AM, Harfe BD, Hill-Harfe KL, et al. Functional genomic analysis of the ADP-ribosylation factor family of GTPases: phylogeny among diverse eukaryotes and function in C-elegans. FASEB J. 2004;18:1834–50. doi:10.1096/fj.04-2273com.

    Article  CAS  PubMed  Google Scholar 

  • Michelet X, Garg S, Wolf BJ, Tuli A, Ricciardi-Castagnoli P, Brenner MB. MHC class II presentation is controlled by the lysosomal small GTPase, Arl8b. J Immunol. 2015;194:2079–88. doi:10.4049/jimmunol.1401072.

    Article  CAS  PubMed  Google Scholar 

  • Nakae I. The arf-like GTPase Arl8 mediates delivery of endocytosed macromolecules to lysosomes in Caenorhabditis elegans. Mol Biol Cell. 2010;21:2434–42.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Okai T, Araki Y, Tada M, Tateno T, Kontani K, Katada T. Novel small GTPase subfamily capable of associating with tubulin is required for chromosome segregation. J Cell Sci. 2004;117:4705–15. doi:10.1242/jcs.01347.

    Article  CAS  PubMed  Google Scholar 

  • Pasqualato S, Renault L, Cherfils J. Arf, Arl, Arp and Sar proteins: a family of GTP-binding proteins with a structural device for “front-back” communication. EMBO Rep. 2002;3:1035–41. doi:10.1093/embo-reports/kvf221.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Price SR, Nightingale M, Tsai SC, Williamson KC, Adamik R, Chen HC, et al. Guanine nucleotide-binding proteins that enhance choleragen Adp-Ribosyltransferase activity - nucleotide and deduced amino-acid sequence of an Adp-ribosylation factor Cdna. Proc Natl Acad Sci USA. 1988;85:5488–91. doi:10.1073/pnas.85.15.5488.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Quinn MT. Low-molecular-weight Gtp-binding proteins and leukocyte signal-transduction. J Leukoc Biol. 1995;58:263–76.

    CAS  PubMed  Google Scholar 

  • Salilew-Wondim D, Holker M, Rings F, Ghanem N, Ulas-Cinar M, Peippo J, et al. Bovine pretransfer endometrium and embryo transcriptome fingerprints as predictors of pregnancy success after embryo transfer. Physiol Genomics. 2010;42:201–18. doi:10.1152/physiolgenomics.00047.2010.

    Article  CAS  PubMed  Google Scholar 

  • Sebald E, Krueger R, King LM, Cohn DH, Krakow D. Isolation of a new member of the ADP-ribosylation like factor gene family, ARL8, from a cartilage cDNA library. Gene. 2003;311:147–51. doi:10.1016/S0378-1119(03)00584-5.

    Article  CAS  PubMed  Google Scholar 

  • Starheim KK, Gromyko D, Evjenth R, Ryningen A, Varhaug JE, Lillehaug JR, et al. Knockdown of human N-alpha-terminal acetyltransferase complex C Leads to p53-dependent apoptosis and aberrant human Arl8b localization. Mol Cell Biol. 2009;29:3569–81. doi:10.1128/Mcb.01909-08.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Stearns T, Kahn RA, Botstein D, Hoyt MA. ADP ribosylation factor is an essential protein in Saccharomyces cerevisiae and is encoded by two genes. Mol Cell Biol. 1990;10:6690–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tamkun JW, Kahn RA, Kissinger M, Brizuela BJ, Rulka C, Scott MP, et al. The Arflike gene encodes an essential Gtp-binding protein in Drosophila. Proc Natl Acad Sci USA. 1991;88:3120–4. doi:10.1073/pnas.88.8.3120.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tuli A, Thiery J, James AM, Michelet X, Sharma M, Garg S, et al. Arf-like GTPase Arl8b regulates lytic granule polarization and natural killer cell-mediated cytotoxicity. Mol Biol Cell. 2013;24:3721–35. doi:10.1091/mbc.E13-05-0259. mbc.E13-05-0259 [pii]

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Life Science 1, School of Medicine, Swansea University, SA2 8PP, Swansea, Wales, UK

    Aiysha Thompson, Riaz Jannoo & Venkateswarlu Kanamarlapudi

Authors
  1. Aiysha Thompson
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Riaz Jannoo
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Venkateswarlu Kanamarlapudi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Venkateswarlu Kanamarlapudi .

Editor information

Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer Science+Business Media LLC

About this entry

Cite this entry

Thompson, A., Jannoo, R., Kanamarlapudi, V. (2016). Arl8b. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_400-1

Download citation

  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_400-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-6438-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

Publish with us

Policies and ethics

Search

Navigation