Definition
PSICS (www.psics.org, Cannon et al. 2010) is a simulator for computing the behavior of neuron models in which the membrane ion channels are expressed as kinetic schemes. It can operate in the stochastic regime where each channel is treated as an independent entity or in the deterministic regime where a population of channels is lumped together as a single continuous process. For extended cells, channels are given precise positions on the membrane before any spatial discretization is performed so exactly the same model can be computed at different spatial and temporal resolutions and with the various channel populations computed stochastically or deterministically. This enables a range of questions to be addressed concerning the influence of channel stochasticity and spatial discretization on the behavior of neurons.
Detailed Description
PSICS operates as a sequential processor taking a declarative model description as input and mapping it through a series of processing and...
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References
Cannon RC, O’Donnell C, Nolan MF (2010) Stochastic ion channel gating in dendritic neurons: morphology dependence and probabilistic synaptic activation of dendritic spikes. PLoS Comput Biol 6(8):e1000886
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© 2014 Springer Science+Business Media New York
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Cannon, R. (2014). PSICS: The Parallel Stochastic Ion Channel Simulator. In: Jaeger, D., Jung, R. (eds) Encyclopedia of Computational Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7320-6_260-2
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DOI: https://doi.org/10.1007/978-1-4614-7320-6_260-2
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Publisher Name: Springer, New York, NY
Online ISBN: 978-1-4614-7320-6
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Latest
PSICS: The Parallel Stochastic Ion Channel Simulator- Published:
- 09 May 2014
DOI: https://doi.org/10.1007/978-1-4614-7320-6_260-2
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Original
PSICS: The Parallel Stochastic Ion Channel Simulator- Published:
- 15 March 2014
DOI: https://doi.org/10.1007/978-1-4614-7320-6_260-1