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Protein Export

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Encyclopedia of Malaria

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Synonyms

Host cell modifications; Protein transport; Virulence factors

Definition

Due to the highly specialized nature of the red blood cell, malaria parasites have created an astonishing and fairly unique example of pathogen-driven host cell modifications that support exponential growth within the cell and avoid detection and elimination by the immune system. These host cell modifications are the topic of this entry.

Introduction

Malaria parasites spend most of their life cycle within cells of their mosquito and mammalian host, with only brief extracellular stages serving the purpose to reach and invade new host cells. Depending on the life cycle stage, various types of host cells are used, posing differing challenges for the intruding parasite. Many of these challenges resemble those faced by other intracellular pathogens that develop in active host cells and involve the acquisition of nutrients for pathogen maturation and proliferation and averting direct and indirect host cell...

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References

  • Atkinson CT, Aikawa M. Ultrastructure of malaria-infected erythrocytes. Blood Cells. 1990;16(2–3):351–68. Review.

    CAS  PubMed  Google Scholar 

  • Bannister LH, Hopkins JM, Fowler RE, Krishna S, Mitchell GH. A brief illustrated guide to the ultrastructure of Plasmodium falciparum asexual blood stages. Parasitol Today. 2000;16(10):427–33. Review.

    Article  CAS  PubMed  Google Scholar 

  • Bhattacharjee S, Stahelin RV, Haldar K. Host targeting of virulence determinants and phosphoinositides in blood stage malaria parasites. Trends Parasitol. 2012;28(12):555–62. Review.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Boddey JA, Cowman AF. Plasmodium nesting: remaking the erythrocyte from the inside out. Annu Rev Microbiol. 2013; 67:243–69. doi: 10.1146/annurev-micro-092412-155730. [Epub ahead of print]

    Google Scholar 

  • Bullen HE, Crabb BS, Gilson PR. Recent insights into the export of PEXEL/HTS-motif containing proteins in Plasmodium parasites. Curr Opin Microbiol. 2012;15(6):699–704.

    Article  CAS  PubMed  Google Scholar 

  • Deponte M, Hoppe HC, Lee MC, Maier AG, Richard D, Rug M, Spielmann T, Przyborski JM. Wherever I may roam: protein and membrane trafficking in P. falciparum-infected red blood cells. Mol Biochem Parasitol. 2012;186(2):95–116. Review.

    Article  CAS  PubMed  Google Scholar 

  • Desai SA. Ion and nutrient uptake by malaria parasite-infected erythrocytes. Cell Microbiol. 2012;14(7):1003–9. Review.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Goldberg DE, Cowman AF. Moving in and renovating: exporting proteins from Plasmodium into host erythrocytes. Nat Rev Microbiol. 2010;8(9):617–21.

    Article  CAS  PubMed  Google Scholar 

  • Lanzer M, Wickert H, Krohne G, Vincensini L, Braun Breton C. Maurer’s clefts: a novel multi-functional organelle in the cytoplasm of Plasmodium falciparum-infected erythrocytes. Int J Parasitol. 2006;36(1):23–36. Review.

    Article  CAS  PubMed  Google Scholar 

  • Maier AG, Cooke BM, Cowman AF, Tilley L. Malaria parasite proteins that remodel the host erythrocyte. Nat Rev Microbiol. 2009;7(5):341–54. Review.

    Article  CAS  PubMed  Google Scholar 

  • Marti M, Spielmann T. Protein export in malaria parasites: many membranes to cross. Curr Opin Microbiol. 2013;16:445–51. doi:pii: S1369-5274(13)00067-2. 10.1016/j.mib.2013.04.010. [Epub ahead of print].

    Google Scholar 

  • Marti M, Baum J, Rug M, Tilley L, Cowman AF. Signal-mediated export of proteins from the malaria parasite to the host erythrocyte. J Cell Biol. 2005;171(4):587–92. Review.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Scherf A, Lopez-Rubio JJ, Riviere L. Antigenic variation in Plasmodium falciparum. Annu Rev Microbiol. 2008;62:445–70. Review.

    Article  CAS  PubMed  Google Scholar 

  • Smith JD, Rowe JA, Higgins MK, Lavstsen T. Malaria’s deadly grip: cytoadhesion of Plasmodium falciparum infected erythrocytes. Cell Microbiol. 2013;15: 1976-83. doi: 10.1111/cmi.12183. [Epub ahead of print].

    Google Scholar 

  • Spielmann T, Gilberger TW. Protein export in malaria parasites: do multiple export motifs add up to multiple export pathways? Trends Parasitol. 2010;26(1):6–10. Review.

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Parasitology Section, Bernhard Nocht Institute for Tropical Medicine, 20359, Hamburg, Germany

    Tobias Spielmann & Tim Wolf Gilberger

  2. Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, 02115, USA

    Matthias Marti

  3. M.G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON, L8N 3Z5, Canada

    Tim Wolf Gilberger

Authors
  1. Tobias Spielmann
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  2. Matthias Marti
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  3. Tim Wolf Gilberger
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Corresponding author

Correspondence to Tobias Spielmann .

Editor information

Editors and Affiliations

  1. Heswall, United Kingdom

    Marcel Hommel

  2. Institut für Tropenmedizin, Universität Tübingen, Tübingen, Germany

    Peter G. Kremsner

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© 2013 Springer Science+Business Media New York

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Spielmann, T., Marti, M., Gilberger, T.W. (2013). Protein Export. In: Hommel, M., Kremsner, P. (eds) Encyclopedia of Malaria. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8757-9_35-1

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  • DOI: https://doi.org/10.1007/978-1-4614-8757-9_35-1

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  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-8757-9

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