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Coenzyme A Biosynthesis

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Encyclopedia of Malaria

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Synonyms

CoA biosynthesis: pantothenate metabolism; Coenzyme A: CoA, CoASH, [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl][(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[[3-oxo-3-(2-sulfanylethylamino)propyl]amino]butyl]hydrogen phosphate (IUPAC name); Pantothenate: vitamin B5

Definition

A biosynthetic process for the generation of coenzyme A. The pathway generally involves five enzyme-mediated steps and pantothenate (vitamin B5), cysteine, and ATP (and sometimes CTP) as substrates.

Introduction

During its intraerythrocytic cycle, the malaria parasite requires an extracellular supply of various nutrients (Kirk and Saliba 2007; Saliba and Kirk 2001b), including the water-soluble vitamin pantothenate (also known as vitamin B5). Pantothenate is a precursor to coenzyme A (CoA), an important coenzyme for many biochemical reactions that has been estimated to be used by as many as 9 % of all known enzymes (Strauss 2010). Early in vivo studies with...

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Authors and Affiliations

  1. Medical School, The Australian National University, Canberra, ACT, 2601, Australia

    Kevin J. Saliba

  2. Research School of Biology, The Australian National University, Canberra, ACT, 2601, Australia

    Kevin J. Saliba & Christina Spry

  3. Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK

    Christina Spry

Authors
  1. Kevin J. Saliba
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  2. Christina Spry
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Correspondence to Kevin J. Saliba .

Editor information

Editors and Affiliations

  1. Heswall, United Kingdom

    Marcel Hommel

  2. Institut für Tropenmedizin, Universität Tübingen, Tübingen, Germany

    Peter G. Kremsner

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Saliba, K.J., Spry, C. (2015). Coenzyme A Biosynthesis. In: Hommel, M., Kremsner, P. (eds) Encyclopedia of Malaria. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8757-9_42-1

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  • DOI: https://doi.org/10.1007/978-1-4614-8757-9_42-1

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