Definitions
Lipoic acid is a cyclic disulfide containing derivative of octanoic acid with redox-active properties. At pH above 4.7, LA is deprotonated and negatively charged and forms lipoate, which is the predominant form found under physiological conditions (Fig. 1).
Structure of lipoate. Lipoic acid primarily exists in deprotonated negatively charged form as lipoate under physiological conditions. The redox-active properties of the cyclic disulfide lead to the generation of reduced and oxidized lipoate
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Müller, S. (2013). Lipoic Acid Metabolism. In: Hommel, M., Kremsner, P. (eds) Encyclopedia of Malaria. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8757-9_9-1
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