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Chronic Mucocutaneous Candidiasis, IL-17F Deficiency

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Encyclopedia of Medical Immunology

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Synonyms

Candidiasis familial 6 (CANDF6)

Definition

Interleukin-17F deficiency is an autosomal dominant disorder that leads to chronic mucocutaneous candidiasis (CMC). CMC is defined as recurrent or persistent mucocutaneous infections caused by fungi of the genus Candida and primarily by the commensal organism Candida albicans (Kirkpatrick 2001; Puel et al. 2012). IL-17F deficiency leads to CMC through impairments in IL-17-mediated immunity.

Introduction

Signaling through the pro-inflammatory cytokine interleukin-17 (IL-17) plays a key role in host defense. In particular, IL-17 protects against fungal and bacterial infections occurring at sites most commonly exposed to microorganisms. These areas include the skin, the oral cavity, as well as the respiratory, gastrointestinal, and vaginal tracts (Veldhoen 2017). The IL-17 family of cytokines and receptors were first identified in the 1990s and were notable in their distinct structural appearance in comparison to other known cytokines...

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Author information

Authors and Affiliations

  1. Department of Pediatrics, BC Children’s Hospital, University of British Columbia, Vancouver, BC, Canada

    Catherine M. Biggs & Stuart E. Turvey

Authors
  1. Catherine M. Biggs
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  2. Stuart E. Turvey
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Corresponding author

Correspondence to Catherine M. Biggs .

Editor information

Editors and Affiliations

  1. Molecular Biology, Monash University Dept. Biochemistry &, Clayton, Victoria, Australia

    Ian MacKay

  2. Autoimmune Disease Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    Noel R. Rose

Section Editor information

  1. British Columbia Children’s Hospital, University of British Columbia, Vancouver, BC, Canada

    Stuart E Turvey

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Biggs, C.M., Turvey, S.E. (2018). Chronic Mucocutaneous Candidiasis, IL-17F Deficiency. In: MacKay, I., Rose, N. (eds) Encyclopedia of Medical Immunology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9209-2_61-1

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  • DOI: https://doi.org/10.1007/978-1-4614-9209-2_61-1

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-9209-2

  • Online ISBN: 978-1-4614-9209-2

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