Pathophysiology of Limbic Epileptic Seizures

Short Description

Pathophysiology in any network of neurons often involves multidimensional factors, including brain injuries, tumors, malformations, and channelopathies as well as genetic predispositions, environmental triggers, and many more. Alterations to one or more of these factors away from normalcy do not always create measurable changes reflective of pathology, but depending upon where in the nervous system they exist and in whom they occur, they often do. The most common outcome of such changes is epilepsy and because of its involvement in memory, emotionality, social interaction, and other processes, one of the most vulnerable networks in the central nervous system for generating behavioral pathologies when deviated from its normal expression is the limbic system.

The limbic system was first outlined by Broca (1878) to identify various structures that surround the brain stem and form the border of the ventricular system. He believed that these structures were primarily...