Synonyms/Abbreviations
Adrenomedullin: AM, ADM
Adrenomedullin 2: AM2, ADM2, Intermedin, IMD
Definition
Adrenomedullin (AM) and Adrenomedullin 2 (AM2) or Intermedin (from here on referred to solely as Adrenomedullin 2) are members of the calcitonin gene-related peptide (CGRP) superfamily of peptides. These peptide hormones are agonists at, and exert their physiological effects through the calcitonin receptor-like receptor (CLR). The peptides have a multitude of different biological activities; foremost among them is AM’s potent activity as a vasodilator. It also plays a key regulatory role in the cardiovascular and lymphatic system, as well as in angiogenesis, and vascular homeostasis. AM2 has effects on the cardiovascular system, adipose tissue, macrophages, and the kidney; it can also activate the sympathetic nervous system.
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References
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Clark, A.J., Ladds, G. (2020). Adrenomedullin/Intermedin. In: Offermanns, S., Rosenthal, W. (eds) Encyclopedia of Molecular Pharmacology. Springer, Cham. https://doi.org/10.1007/978-3-030-21573-6_5055-1
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DOI: https://doi.org/10.1007/978-3-030-21573-6_5055-1
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