Definition
Tubulocystic carcinoma is an uncommon multicystic renal cell tumor.
Clinical Features
Incidence
The tumor comprises less than 1% of all renal carcinomas.
Age
Tubulocystic carcinoma occurs most commonly in the fifth and sixth decades of life.
Sex
There is a male predominance.
Site
There is no site predilection.
Treatment
Radical nephrectomy is generally recommended, but partial nephrectomy may be performed for small tumors located in the superficial renal cortex.
Outcome
They usually display an indolent behavior with a few cases with metastasis or recurrence.
Macroscopy
The tumors are solitary well-circumscribed multicystic renal mass. They are frequently 4 cm or less and composed of multiple small- to intermediate-sized cysts and have a white and sponge-like cut surface.
Microscopy
The cysts above described are lined by a single layer of flattened, cuboidal, and hobnailed eosinophilic renal cells with enlarged nuclei with prominent (ISUP/WHO 2016 grade 3) nucleoli (Fig. 1)....
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References and Further Reading
Amin, M. B., MacLennan, G. T., Gupta, R., et al. (2009). Tubulocystic carcinoma of the kidney: Clinicopathologic analysis of 31 cases of a distinctive rare subtype of renal cell carcinoma. The American Journal of Surgical Pathology, 33, 384–392.
Sarungbam, J., Mehra, R., Tomlins, S. A., et al. (2019). Tubulocystic renal cell carcinoma: A distinct clinicopathologic entity with a characteristic genomic profile. Mod Pathol, 32, 701–709.
Yang, X. J., Zhou, M., Hes, O., et al. (2008). Tubulocystic carcinoma of the kidney: Clinicopathologic and molecular characterization. The American Journal of Surgical Pathology, 32, 177–187.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Switzerland AG
About this entry
Cite this entry
Caliò, A., Segala, D., Martignoni, G. (2020). Tubulocystic Renal Cell Carcinoma. In: Raspollini, M.R., Lopez-Beltran, A. (eds) Uropathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-030-41894-6_4962
Download citation
DOI: https://doi.org/10.1007/978-3-030-41894-6_4962
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-41893-9
Online ISBN: 978-3-030-41894-6
eBook Packages: MedicineReference Module Medicine