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Renal Cell Carcinoma, Unclassified

  • Reference work entry
  • First Online:
Uropathology

Part of the book series: Encyclopedia of Pathology ((EP))

  • 6 Accesses

Definition

Unclassified renal cell carcinoma is not a distinct type of renal cell carcinoma but a diagnostic category for tumors which do not fit into any of the recognized subtypes of renal cell carcinoma.

Clinical Features

  • Incidence

    These tumors generally account for 0.7–5.7% of renal cell carcinomas (Moch et al. 2016).

  • Age

    It occurs in any age.

  • Sex

    There is no gender predominance.

  • Site

    There is no site predilection.

  • Treatment

    Radical or partial nephrectomy is the standard of care surgery.

  • Outcome

    Outcome is based on prognostic features such as TNM stage, pathologic grade, and the presence of tumor coagulative necrosis which should be reported. Previous studies suggest that unclassified renal cell carcinomas are usually aggressive neoplasms, mostly based on the fact that they present at an advanced stage. More recent studies suggest that might be of similar aggressiveness to clear cell renal cell carcinoma when matched by pT status.

Macroscopy

No specific gross features associated...

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References and Further Reading

  • Lopez-Beltran, A., Kirkali, Z., Montironi, R., et al. (2012). Unclassified renal cell carcinoma: A report of 56 cases. BJU International, 110, 786–793.

    Article  PubMed  Google Scholar 

  • Moch, H., Humprey, P. A., Ulbright, T. M., & Reuter, V. E. (2016). WHO classification of Tumours of the urinary system and male genital organs. Lyon: Cancer IARC.

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  • Perrino, C. M., Grignon, D. J., Williamson, S. R., Idrees, M. T., Eble, J. N., & Cheng, L. (2018). Morphological spectrum of renal cell carcinoma, unclassified: An analysis of 136 cases. Histopathology, 72(2), 305–319.

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Diagnostic and Public Health, Section of Pathology, University of Verona, Verona, Italy

    Anna Caliò & Guido Martignoni

  2. Department of Pathology, Pederzoli Hospital, Peschiera del Garda, Italy

    Diego Segala & Guido Martignoni

  3. Pathology Service, Champalimaud Clinical Center, Lisbon, Portugal

    Antonio Lopez-Beltran

  4. Unit of Anatomic Pathology, Department of Surgery, Cordoba University Medical School, Cordoba, Spain

    Antonio Lopez-Beltran

Authors
  1. Anna Caliò
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  2. Diego Segala
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  3. Antonio Lopez-Beltran
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  4. Guido Martignoni
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Corresponding author

Correspondence to Guido Martignoni .

Editor information

Editors and Affiliations

  1. Histopathology and Molecular Diagnostics, University Hospital Careggi, Florence, Italy

    Maria Rosaria Raspollini

  2. Pathology Service, Champalimaud Clinical Center, Lisbon, Portugal

    Antonio Lopez-Beltran

  3. Unit of Anatomic Pathology, Department of Surgery, Cordoba University Medical School, Cordoba, Spain

    Antonio Lopez-Beltran

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Cite this entry

Caliò, A., Segala, D., Lopez-Beltran, A., Martignoni, G. (2020). Renal Cell Carcinoma, Unclassified. In: Raspollini, M.R., Lopez-Beltran, A. (eds) Uropathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-030-41894-6_4963

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  • DOI: https://doi.org/10.1007/978-3-030-41894-6_4963

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-41893-9

  • Online ISBN: 978-3-030-41894-6

  • eBook Packages: MedicineReference Module Medicine

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