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Chronic Myeloid Leukemia and Polycythemia Vera Progression

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Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

  • 234 Accesses

Synonyms

Acceleration; Blast crisis; Blast phase; Spent phase

Definition

Myeloproliferative neoplasms, including chronic myeloid leukemia (CML) and polycythemia vera (PV), may progress from a steady-state phase (chronic phase) with sufficient production of mature blood cells to an accelerated phase with deterioration of hematologic blood parameters and/or organomegaly. Chronic and accelerated phase may be followed by a blast phase with more than 20% immature blasts in the blood or bone marrow. Transition from chronic to accelerated and blast phase, respectively, is defined by varying parameters, which according to WHO (Vardiman et al. 2017) are summarized in Table 1.

Table 1 Accelerated and blast phase in CML and PV
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Authors and Affiliations

  1. Institute of Pathology Hannover Medical School, Hannover, Germany

    Hans H. Kreipe

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  1. Hans H. Kreipe
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Correspondence to Hans H. Kreipe .

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Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Kreipe, H.H. (2019). Chronic Myeloid Leukemia and Polycythemia Vera Progression. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_3858-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_3858-1

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