Definition
Collagenous spherulosis (CS) of the breast is a benign lesion most frequently associated with other benign proliferative processes, including papilloma, papillary duct hyperplasia, radial sclerosing lesions, sclerosing adenosis, and atypical ductal hyperplasia. Originally reported by Clement et al. in 1987, the lesion was first described as an incidental microscopic finding of intraluminal clusters of collagen-rich, eosinophilic, or star-shaped fibrillar spherules (Clement et al. 1987).
Clinical Features
Incidence: Collagenous spherulosis (CS) is very rare, with an estimated incidence of less than 1% in excisional specimens (Resetkova et al. 2006) and about 0.2% in cytology material (Sola Perez et al. 1993). CS may go unrecognized in about 48% of cases or may be misdiagnosed as atypical hyperplasia in 17% of cases or as in situ and/or invasive carcinoma in 11% of cases (Mooney et al. 1999).
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References and Further Reading
Clement, P. B., Young, R. H., & Azzopardi, J. G. (1987). Collagenous spherulosis of the breast. American Journal of Surgical Pathology, 11, 411–417.
Mooney, E. E., Kayani, N., & Tavassoli, F. A. (1999). Spherulosis of the breast. A spectrum of mucinous and collagenous lesions. Archives of Pathology & Laboratory Medicine, 123, 626–630.
Rabban, J. T., Swain, R. S., Zaloudek, C. J., Chase, D. R., & Chen, Y. Y. (2006). Immunophenotypic overlap between adenoid cystic carcinoma and collagenous spherulosis of the breast: Potential diagnostic pitfalls using myoepithelial markers. Modern Pathology, 19, 1351–1357.
Reis-Filho, J. S., Fulford, L. G., Crebassa, B., et al. (2004). Collagenous spherulosis in an adenomyoepithelioma of the breast. Journal of Clinical Pathology, 57, 83–86.
Resetkova, E., Albarracin, C., & Sneige, N. (2006). Collagenous spherulosis of breast: Morphologic study of 59 cases and review of the literature. American Journal of Surgical Pathology, 30, 20–27.
Sola Perez, J., Perez-Guillermo, M., Bas Bernal, A., et al. (1993). Diagnosis of collagenous spherulosis of the breast by fine needle aspiration cytology: A report of two cases. Acta Cytologica, 37, 725–728.
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Skalova, A. (2018). Collagenous Spherulosis. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4744-1
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DOI: https://doi.org/10.1007/978-3-319-28845-1_4744-1
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