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Prostatic Acinar Adenocarcinoma, Microcystic Variant

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Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

  • 39 Accesses

Definition

Microcystic acinar adenocarcinoma is a variant of acinar adenocarcinoma characterized by gland dilatation with intermediate-sized glands that are, on average, 10 times the size of usual small acinar adenocarcinoma glands (Humphrey 2018; Yaskiv et al. 2010).

Clinical Features

  • Incidence

    About 11% of usual acinar adenocarcinomas exhibit microcystic foci in radical prostatectomy cases.

  • Age

    Mainly among patients aged 60–70 years.

  • Sex

    Male.

  • Site

    Mainly peripheral zone of the prostate.

  • Treatment

    Similar to those of usual acinar adenocarcinoma.

  • Outcome

    Similar to those of usual acinar adenocarcinoma: the presence of microcystic features in prostatic adenocarcinoma is not likely to be of prognostic significance.

Macroscopy

Similar to those of usual acinar adenocarcinoma. There are no reported gross descriptions of microcystic pattern of adenocarcinoma.

Microscopy

The glands are on average 10 times the size of usual small acinar adenocarcinoma glands and typically show rounded...

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References and Further Reading

  • Humphrey, P. A. (2018). Variants of acinar adenocarcinoma of the prostate mimicking benign conditions. Modern Pathology, 31(S1), S64–S70.

    Article  Google Scholar 

  • Yaskiv, O., Cao, D., & Humphrey, P. A. (2010). Microcystic adenocarcinoma of the prostate: A variant of pseudohyperplastic and atrophic patterns. American Journal of Surgical Pathology, 34, 556–561.

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Institute of Pathological Anatomy and Histopathology, Polytechnic University of the Marche Region (Ancona), Ancona, Italy

    Alessia Cimadamore & Rodolfo Montironi

  2. Histopathology and Molecular Diagnostics, University Hospital Careggi, Florence, Italy

    Maria Rosaria Raspollini

Authors
  1. Alessia Cimadamore
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  2. Maria Rosaria Raspollini
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  3. Rodolfo Montironi
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Corresponding author

Correspondence to Rodolfo Montironi .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Cimadamore, A., Raspollini, M.R., Montironi, R. (2019). Prostatic Acinar Adenocarcinoma, Microcystic Variant. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4904-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_4904-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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