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Synovial Chondromatosis

  • Living reference work entry
  • First Online:
Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

  • 27 Accesses

Synonyms

Synovial osteochondromatosis

Definition

An uncommon benign neoplasm characterized by formation of multiple nodules of hyaline cartilage, typically present in the subsynovial connective tissue of joints, tendons, and bursae (Sciot and Bridge 2013).

Clinical Features

  • Incidence

    This neoplasm is rare without detailed data reported in literature about the incidence or the prevalence.

  • Age

    Synovial chondromatosis affects patients with a wide range from childhood to late adult life with a peak incidence in the fifth decade of life.

  • Sex

    Males are affected twice as often as females, with a ratio of 1.8:1.

  • Site

    It occurs usually in large joints, such as the knee, hip, elbow, or shoulder joint with the formation of small, metaplastic cartilaginous or osseocartilaginous nodules of varying size attached to the synovial membrane of the joint, tendon sheath, or lining the adjacent extra-articular bursa (Sciot and Bridge 2013; Folpe and Inwards 2010).

  • Treatment

    Synovial chondromatosis is...

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References and Further Reading

  • Amary, M. F., Bacsi, K., Maggiani, F., Damato, S., Halai, D., Berisha, F., Pollock, R., O’Donnell, P., Grigoriadis, A., Diss, T., Eskandarpour, M., Presneau, N., Hogendoorn, P. C., Futreal, A., Tirabosco, R., & Flanagan, A. M. (2011). IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours. The Journal of Pathology, 224, 334–343.

    Article  CAS  Google Scholar 

  • Bertoni, F., Unni, K. K., Beabout, J. W., & Sim, F. H. (1991). Chondrosarcomas of the synovium. Cancer, 67, 155–162.

    Article  CAS  Google Scholar 

  • Buddingh, E. P., Krallman, P., Neff, J. R., Nelson, M., Liu, J., & Bridge, J. A. (2003). Chromosome 6 abnormalities are recurrent in synovial chondromatosis. Cancer Genetics and Cytogenetics, 140(1), 18–22.

    Article  CAS  Google Scholar 

  • Folpe, A. W., & Inwards, C. Y. (2010). Bone and soft tissue pathology. Philadelphia: Saunders Elsevier.

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  • Sciot, R., & Bridge, J. A. (2013). Synovial chondromatosis. In C. D. M. Fletcher, J. A. Bridge, P. C. W. Hogendoorn, & F. Mertens (Eds.), World Health Organization classification of tumours. Pathology and genetics of tumours of soft tissue and bone (p. 261). IARC: Lyon.

    Google Scholar 

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Author information

Authors and Affiliations

  1. IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

    Alberto Righi

Authors
  1. Alberto Righi
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Corresponding author

Correspondence to Alberto Righi .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Righi, A. (2020). Synovial Chondromatosis. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_5470-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_5470-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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