Synonyms
Agranulocytic colitis; Ileocaecal syndrome; Neutropenic enteropathy; Phlegmonous caecitis; Typhlitis
Definition
Neutropenic enterocolitis is an inflammatory and necrotizing process, predominantly involving the caecum, occurring in neutropenic patients. Because of its caecal localization, the disease is also named typhlitis, deriving from the Greek word typhlon, meaning caecum.
Neutropenic enterocolitis is a life-threatening disease for the first time described in children with leukemia in 1933. It is most commonly observed after chemotherapy for a hematological or a lymphoproliferative malignancy, but it may also found in relationship to a wide variety of solid tumors, e.g., colorectal, breast, lung, and ovarian cancer. It is also reported in patients with an acquired immunodeficiency syndrome (AIDS), aplastic anemia, cyclic neutropenia, after an autologous stem cell transplantation or in those, showing idiosyncratic drug reactions involving antibiotics or immunosuppressives....
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References and Further Reading
Cloutier, R. L. (2009). Neutropenic enterocolitis. Emergency Medicine Clinics of North America, 27, 415–422.
Ebert, E. C., & Hagspiel, K. D. (2012). Gastrointestinal manifestations of leukemia. Journal of Gastroenterology and Hepatology, 27, 458–463.
Fenoglio-Preiser, C. M., Noffsinger, A. E., Stemmermann, G. N., Lantz, P. E., & Isaacson, P. G. (2008). Gastrointestinal pathology. An atlas and text (3rd ed., pp. 838–841). Philadelphia: Lippincott, Williams & Wilkins.
Gil, L., Poplawski, D., Mol, A., Nowicki, A., Schneider, A., & Komarnicki, M. (2012). Neutropenic enterocolitis after high-dose chemotherapy and autologous stem cell transplantation: Incidence, risk factors, and outcome. Transplant Infectious Disease: An Official Journal of the Transplantation Society, 15(1), 1–7. doi:10.111/j.1399-3062.2012:0:1 7.
Ullery, B. W., Pieracci, F. M., Rodney, J. R., & Barie, P. S. (2009). Neutropenic enterocolitis. Surgical Infections, 10, 307–314.
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Driessen, A. (2017). Neutropenic Colitis. In: Carneiro, F., Chaves, P., Ensari, A. (eds) Pathology of the Gastrointestinal Tract. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-40560-5_1444
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DOI: https://doi.org/10.1007/978-3-319-40560-5_1444
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