Generic Name
Paliperidone
Brand Name
Invega, Invega Sustenna, Invega Trinza
Class
Antipsychotics, second generation, mood stabilizer
Proposed Mechanism(s) of Action
Combination of central dopamine D2 and serotonin 5-HT2A receptor antagonism
Indication
For the treatment of schizophrenia and manic or mixed bipolar 1 episodes
Off-Label Use
Agitation associated with a myriad of psychiatric conditions and dementia. Borderline personality disorder. Disruptive behavioral disorders associated with childhood.
Side Effects
Serious
Increased risk of mortality in elderly patients with dementia-related psychosis, mania. Extrapyramidal symptoms, prolongation of Q-T interval, agranulocytosis.
Common
Headache, dizziness, somnolence, dry mouth, nausea, tachycardia, diarrhea, orthostatic hypotension, weight gain.
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References and Readings
Physicians’ desk reference (71st ed.) (2017). Montvale: Thomson PDR.
Stahl, S. M. (2007). Essential psychopharmacology: The prescriber’s guide (2nd ed.). New York: Cambridge University Press.
Additional Information
Drug Interaction Effects. http://www.drugs.com/drug_interactions.html
Drug Molecule Images. http://www.worldofmolecules.com/drugs/
Frånberg, O., Marcus, M. M., Ivanov, V., Schilström, B., Shahid, M., & Svensson, T. H. (2009). Asenapine elevates cortical dopamine, noradrenaline and serotonin release. Evidence for activation of cortical and subcortical dopamine systems by different mechanisms. Psychopharmacology, 204(2), 251–264.
Free Drug Online. www.medscape.com
Free Drug Online and PDA Software. www.epocrates.com
Free Drug Online Centerwatch. https://www.centerwatch.com/drug-information/fda-approved-drugs/therapeutic-area/17/psychiatry-psychology
Gene-Based Estimate of Drug interactions. http://mhc.daytondcs.com:8080/cgi bin/ddiD4?ver=4&task=getDrugList
Marston, H. M., Young, J. W., Martin, F. D., Serpa, K. A., Moore, C. L., Wong, E. H., Gold, L., Meltzer, L. T., Azar, M. R., Geyer, M. A., & Shahid, M. (2009). Asenapine effects in animal models of psychosis and cognitive function. Psychopharmacology, 206(4), 699–714.
Pill Identification. http://www.drugs.com/pill_identification.html
Potkin, S. G., Cohen, M., & Panagides, J. (2007). Efficacy and tolerability of asenapine in acute schizophrenia: A placebo- and risperidone-controlled trial. The Journal of Clinical Psychiatry, 68(10), 1492–1500.
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Gonzalez, E.A. (2018). Paliperidone. In: Kreutzer, J.S., DeLuca, J., Caplan, B. (eds) Encyclopedia of Clinical Neuropsychology. Springer, Cham. https://doi.org/10.1007/978-3-319-57111-9_9271
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DOI: https://doi.org/10.1007/978-3-319-57111-9_9271
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