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Associations of Cytokine Polymorphisms with Immunosenescence

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Handbook of Immunosenescence

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Abstract

The aging is a process characterized by progressive loss of function of the body, leading to decreased ability to environmental changes and maintenance of the homeostasis. Current data showing that aging processes may be associated with alterations in the immune system suggest that some of the genetic determinants of senescence might be polymorphic genes that regulate immune responses. In this chapter we will review the data on the role of cytokine gene polymorphisms in human longevity.

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Authors and Affiliations

  1. Department of Clinical Immunology, University Hospital “Alexandrovska”, Medical University, Sofia, Bulgaria

    Elissaveta Naumova & Milena Ivanova

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  1. Elissaveta Naumova
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  2. Milena Ivanova
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Editors and Affiliations

  1. Division of Geriatrics Research Center on Aging, University of Sherbrooke Dept. of Medicine, Sherbrooke, Québec, Canada

    Tamas Fulop

  2. Dept of Experimental Pathology, University of Bologna, Bologna, Italy

    Claudio Franceschi

  3. Institute for Health and Life Sciences, Tokyo, Japan

    Katsuiku Hirokawa

  4. Center for Medical Research, University of Tübingen, Tübingen, Germany

    Graham Pawelec

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Naumova, E., Ivanova, M. (2018). Associations of Cytokine Polymorphisms with Immunosenescence. In: Fulop, T., Franceschi, C., Hirokawa, K., Pawelec, G. (eds) Handbook of Immunosenescence. Springer, Cham. https://doi.org/10.1007/978-3-319-64597-1_32-1

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