Synonyms
Hodgkin’s disease
Definition
Hodgkin lymphoma (HL) is a B-cell neoplasm characterized morphologically by the presence of relatively rare atypical neoplastic cells (Reed-Sternberg cells, Hodgkin cells, or LP cells) in a background of nonneoplastic, variably heterogeneous inflammatory infiltrate. HL is broadly divided in classical HL, which represent 95% of cases, and nodular lymphocyte predominant HL (NLPHL), which constitutes the remainder 5%. Classical HL is further subdivided into four categories: nodular sclerosis, mixed cellularity, lymphocyte-rich, and lymphocyte-depleted, based on cellular composition and different histologic pattern (Mani and Jaffe 2009).
Clinical Features
Incidence
In the US and Western Europe, HL has an incidence of 3–5 cases/100,000/year, while in Japan the incidence is about threefold lower. In patients with AIDS, the risk of developing HL is ten times higher than in an HIV-negative individual.
Age
Classical HL has a bimodal age distribution, with...
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References and Further Reading
Eberle, F. C., Mani, H., & Jaffe, E. S. (2009). Histopathology of Hodgkin’s lymphoma. Cancer Journal, 15(2), 129–137.
Eichenauer, D. A., Engert, A., & Dreyling, M. (2011). Hodgkin's lymphoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Annals of Oncology, 22(Suppl 6), vi55–vi58.
Hoppe, R. T., Advani, R. H., Ai, W. Z., Ambinder, R. F., Bello, C. M., Bierman, P. J., et al. (2011). Hodgkin lymphoma. Journal of the National Comprehensive Cancer Network, 9(9), 1020–1058.
Kuppers, R. (2009). Molecular biology of Hodgkin lymphoma. Hematology American Society of Hematology Education Program, 2009(1), 491–496.
Mani, H., & Jaffe, E. S. (2009). Hodgkin lymphoma: An update on its biology with new insights into classification. Clinical Lymphoma & Myeloma, 9(3), 206–216.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG, part of Springer Nature
About this entry
Cite this entry
Olteanu, H. (2018). Hodgkin Lymphoma, Mediastinal. In: Allen, T.C., Suster, S. (eds) Pathology of the Pleura and Mediastinum. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-66796-6_25
Download citation
DOI: https://doi.org/10.1007/978-3-319-66796-6_25
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-66795-9
Online ISBN: 978-3-319-66796-6
eBook Packages: MedicineReference Module Medicine