Historical Background
The cytoskeleton of eukaryotic cells is a dynamic network based on the cross-talk between three types of filaments: microtubules, actin, and intermediate filaments. This network interacts with a high number of associated proteins that regulate and modulate filaments assembly and dynamics. Altogether, they have multiple roles in cells, such as cell size and shape regulation, cell-cell communication, cell migration, cell division, intracellular localization and coordination of organelles functions, and integration of extracellular signals. Moreover, the cytoskeleton also allows the constant flux of molecules, promoting the interaction between proteins, substrates, and cofactors (Fletcher and Mullins 2010; Fischer and Fowler 2015).
The Microtubule Cytoskeleton Dynamics
As one of the cytoskeleton components, microtubules play critical roles in a range of cellular processes. They function as...
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Camelo, C., Peneda, C., Carmona, B., Soares, H. (2018). TBCC. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101508
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