Historical Background
Adaptor proteins are crucial members of signaling cascades that bind to multiple pattern recognition receptors to streamline the inflammatory response. One such adaptor molecule is MAVS (also known as IPS1, VISA, or CARDIF), which is present downstream of RIG-I and MDA-5, cytosolic sensors of viral genomic material (Seth et al. 2005). In the year 2005, several groups independently identified an adaptor protein that controls activation of IKK and TBK1/IKKε downstream of RIG-I. This adaptor molecule was named MAVS (Seth et al. 2005), IPS-1 (Kawai et al. 2005), VISA (Xu et al. 2005), or CARDIF (Meylan et al. 2005). However, MAVS is now the standard nomenclature accepted in the scientific community. Upon activation, MAVS initiates downstream signaling cascades leading to the production of inflammatory cytokines, antimicrobial peptides, and activation of several transcription factors (Li et al. 2011). Its importance is now recognized not only in viral infection but...
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Mohning, M.P., Atif, S.M. (2018). MAVS-Mitochondrial Antiviral Signaling Protein. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101513
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