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DREAM (Downstream Regulatory Element Antagonist Modulator)

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Encyclopedia of Signaling Molecules

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Synonyms

Calsenilin; Downstream regulatory element antagonist modulator; DREAM; KChIP3; Potassium channel-interacting protein 3

Historical Background

In 1998, Carrión et al. discovered a 110 kDa protein complex present in nuclear extracts of human neuroblastoma cells that could bind to a small region of DNA (+36 to +44 relative to the transcription start site) within the 5′ untranslated region (5′-UTR) of the human prodynorphin gene. Occupancy of this DNA element, termed the downstream regulatory element (DRE), by the protein complex caused a significant attenuation in prodynorphin gene transcription (Carrión et al. 1998). Utilizing a double-stranded DRE oligonucleotide probe to screen a human caudate expression library, Carrión et al. (1999) subsequently cloned the gene encoding for the DRE-binding protein, which they named downstream regulatory element antagonist modulator (DREAM). Electrophoretic mobility shift assays (EMSAs) confirmed that DREAM can bind to DRE and that the...

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References

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Authors and Affiliations

  1. Department of Biology, University of Toronto Mississauga, 3359 Mississauga Road, Mississauga, ON, Canada

    Stephen Pastore & Hai-Ying Mary Cheng

  2. Department of Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, ON, Canada

    Stephen Pastore & Hai-Ying Mary Cheng

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  1. Stephen Pastore
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  2. Hai-Ying Mary Cheng
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Correspondence to Hai-Ying Mary Cheng .

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Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Pastore, S., Cheng, HY.M. (2018). DREAM (Downstream Regulatory Element Antagonist Modulator). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101763

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