Historical Background
The Brain-Expressed X-linked (BEX) is a family of five proteins including BEX1, BEX2, BEX3, BEX4, and BEX5 (Kazi et al. 2015). BEX-family proteins are characterized by a highly conserved BEX domain (Fig. 1). Function of the BEX domain is still poorly understood. Recent studies identified a role of BEX domain containing proteins in growth control. All BEX genes cluster to the human Xq22 chromosome. BEX3 was the first BEX-family protein described and was initially named HGR74 (Rapp et al. 1990).
BEX family proteins. All BEX family proteins share a characteristic BEX domain. BEX2 and BEX3 have an uncharacterized N-terminal region
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References
Alvarez E, Zhou W, Witta SE, Freed CR. Characterization of the Bex gene family in humans, mice, and rats. Gene. 2005;357:18–28. https://doi.org/10.1016/j.gene.2005.05.012.
Calvo L, Anta B, Lopez-Benito S, Martin-Rodriguez C, Lee FS, Perez P, et al. Bex3 Dimerization Regulates NGF-Dependent Neuronal Survival and Differentiation by Enhancing trkA Gene Transcription. J Neurosci. 2015;35:7190–202. https://doi.org/10.1523/JNEUROSCI.4646-14.2015.
Descamps S, Toillon RA, Adriaenssens E, Pawlowski V, Cool SM, Nurcombe V, et al. Nerve growth factor stimulates proliferation and survival of human breast cancer cells through two distinct signaling pathways. J Biol Chem. 2001;276:17864–70. https://doi.org/10.1074/jbc.M010499200.
Du C, Fang M, Li Y, Li L, Wang X. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell. 2000;102:33–42.
Kazi JU, Kabir NN, Rönnstrand L. Brain-Expressed X-linked (BEX) proteins in human cancers. Biochim Biophys Acta. 2015;1856:226–33. https://doi.org/10.1016/j.bbcan.2015.09.001.
Kim AJ, Lee CS, Schlessinger D. Bex3 associates with replicating mitochondria and is involved in possible growth control of F9 teratocarcinoma cells. Gene. 2004;343:79–89. https://doi.org/10.1016/j.gene.2004.08.031.
Kimura MT, Irie S, Shoji-Hoshino S, Mukai J, Nadano D, Oshimura M, et al. 14-3-3 is involved in p75 neurotrophin receptor-mediated signal transduction. J Biol Chem. 2001;276:17291–300. https://doi.org/10.1074/jbc.M005453200.
Lindblad O, Li T, Su X, Sun J, Kabir NN, Levander F, et al. BEX1 acts as a tumor suppressor in acute myeloid leukemia. Oncotarget. 2015;6(25):21395–405.
Mukai J, Hachiya T, Shoji-Hoshino S, Kimura MT, Nadano D, Suvanto P, et al. NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR. J Biol Chem. 2000;275:17566–70. https://doi.org/10.1074/jbc.C000140200.
Mukai J, Shoji S, Kimura MT, Okubo S, Sano H, Suvanto P, et al. Structure-function analysis of NADE: identification of regions that mediate nerve growth factor-induced apoptosis. J Biol Chem. 2002;277:13973–82. https://doi.org/10.1074/jbc.M106342200.
Mukai J, Suvant P, Sato TA. Nerve growth factor-dependent regulation of NADE-induced apoptosis. Vitam Horm. 2003;66:385–402.
Park JA, Lee JY, Sato TA, Koh JY. Co-induction of p75NTR and p75NTR-associated death executor in neurons after zinc exposure in cortical culture or transient ischemia in the rat. J Neurosci. 2000;20:9096–103.
Rapp G, Freudenstein J, Klaudiny J, Mucha J, Wempe F, Zimmer M, et al. Characterization of three abundant mRNAs from human ovarian granulosa cells. DNA Cell Biol. 1990;9:479–85.
Sano H, Mukai J, Monoo K, Close LG, Sato TA. Expression of p75NTR and its associated protein NADE in the rat cochlea. Laryngoscope. 2001;111:535–8. https://doi.org/10.1097/00005537-200103000-00027.
Sharov AA, Piao Y, Matoba R, Dudekula DB, Qian Y, VanBuren V, et al. Transcriptome analysis of mouse stem cells and early embryos. PLoS Biol. 2003;1:E74. https://doi.org/10.1371/journal.pbio.0000074.
Tong X, Xie D, Roth W, Reed J, Koeffler HP. NADE (p75NTR-associated cell death executor) suppresses cellular growth in vivo. Int J Oncol. 2003;22:1357–62.
Yasui S, Tsuzaki K, Ninomiya H, Floricel F, Asano Y, Maki H, et al. The TSC1 gene product hamartin interacts with NADE. Mol Cell Neurosci. 2007;35:100–8. https://doi.org/10.1016/j.mcn.2007.02.007.
Yoon K, Jang HD, Lee SY. Direct interaction of Smac with NADE promotes TRAIL-induced apoptosis. Biochem Biophys Res Commun. 2004;319:649–54. https://doi.org/10.1016/j.bbrc.2004.05.043.
Zhao J, Meyerkord CL, Du Y, Khuri FR, Fu H. 14-3-3 proteins as potential therapeutic targets. Semin Cell Dev Biol. 2011;22:705–12. https://doi.org/10.1016/j.semcdb.2011.09.012.
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Kazi, J.U., Kabir, N.N., Rönnstrand, L. (2018). BEX3. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101775
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