Synonyms
IL-13Rα: CD213a1; CT19; IL-13 receptor alpha 1; IL-13R; IL-13R alpha 1; IL-13RA1; Interleukin 12 receptor alpha 1; NR4
IL-13Rα2: CD213a2; IL-13 receptor alpha 2; IL-13BP; IL-13R alpha 2; IL-13Ra2; Il13rA2; Il13ra2; IL-13Ralpha2; Interleukin 13 receptor alpha 2
IL-4Rα: CD124; IL-4 receptor alpha; IL-4RA; Interleukin 4 receptor, alpha
Historical Background
The IL-4 and IL-13 receptor subunits were among the first cytokine receptor systems described in the 1980s enabling the discovery of cytokine cell signaling, receptor subunit formation and cytokine regulation of immune responses. The IL-4R complex has been shown to be central in regulating type II-mediated immunity and inflammation toward extracellular parasitic infections, regulation of B-cell antibody isotype class switching and affinity maturation, and the progression of allergy, asthma, and atopic dermatitis in susceptible individuals. Many studies over the last 20 years have revealed the role of IL-4/IL-13R in the...
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Andrews AL, Nordgren IK, Campbell-Harding G, Holloway JW, Holgate ST, Davies DE, et al. The association of the cytoplasmic domains of interleukin 4 receptor alpha and interleukin 13 receptor alpha 2 regulates interleukin 4 signaling. Mol Biosyst. 2013;9(12):3009–14. PubMed PMID: 24056919.
Badalyan V, Thompson R, Addo K, Borthwick LA, Fisher AJ, Ort T, et al. TNF-alpha/IL-17 synergy inhibits IL-13 bioactivity via IL-13Ralpha2 induction. J Allergy Clin Immunol. 2014;134(4):975-8.e5. PubMed PMID: 24954262.
Cheng E, Souza RF, Spechler SJ. Tissue remodeling in eosinophilic esophagitis. Am J Physiol Gastrointest Liver Physiol. 2012;303(11):G1175–87. PubMed PMID: 23019192.
Daines MO, Hershey GK. A novel mechanism by which interferon-gamma can regulate interleukin (IL)-13 responses. Evidence for intracellular stores of IL-13 receptor alpha −2 and their rapid mobilization by interferon-gamma. J Biol Chem. 2002;277(12):10387–93. PubMed PMID: 11786536.
David M, Ford D, Bertoglio J, Maizel AL, Pierre J. Induction of the IL-13 receptor alpha2-chain by IL-4 and IL-13 in human keratinocytes: involvement of STAT6, ERK and p38 MAPK pathways. Oncogene. 2001;20(46):6660–8.
Duerr CU, McCarthy CD, Mindt BC, Rubio M, Meli AP, Pothlichet J, et al. Type I interferon restricts type 2 immunopathology through the regulation of group 2 innate lymphoid cells. Nat Immunol. 2016;17(1):65–75. PubMed PMID: 26595887.
Fichtner-Feigl S, Strober W, Kawakami K, Puri RK, Kitani A. IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis. Nat Med. 2006;12(1):99–106. Epub 2005 Dec 4. PubMed PMID: 16327802.
Halim TY, Hwang YY, Scanlon ST, Zaghouani H, Garbi N, Fallon PG, et al. Group 2 innate lymphoid cells license dendritic cells to potentiate memory TH2 cell responses. Nat Immunol. 2016;17(1):57–64. PubMed PMID: 26523868. Pubmed Central PMCID: PMC4685755.
He CH, Lee CG, Dela Cruz CS, Lee CM, Zhou Y, Ahangari F, et al. Chitinase 3-like 1 regulates cellular and tissue responses via IL-13 receptor alpha2. Cell Rep. 2013;4(4):830–41. PubMed PMID: 23972995.
Heller NM, Qi X, Junttila IS, Shirey KA, Vogel SN, Paul WE, et al. Type I IL-4Rs selectively activate IRS-2 to induce target gene expression in macrophages. Sci Signal. 2008;1(51):ra17. PubMed PMID: 19109239.
Jackson RJ, Worley M, Trivedi S, Ranasinghe C. Novel HIV IL-4R antagonist vaccine strategy can induce both high avidity CD8 T and B cell immunity with greater protective efficacy. Vaccine. 2014;20(14):01136-0. PubMed PMID: 25151041.
Lupardus PJ, Birnbaum ME, Garcia KC. Molecular basis for shared cytokine recognition revealed in the structure of an unusually high affinity complex between IL-13 and IL-13Ralpha2. Structure. 2010;18(3):332–42. PubMed PMID: 20223216.
Mosley B, Beckmann MP, March CJ, Idzerda RL, Gimpel SD, VandenBos T, et al. The murine interleukin-4 receptor: molecular cloning and characterization of secreted and membrane bound forms. Cell. 1989;59(2):335–48. PubMed PMID: 2805066.
Newcomb DC, Zhou W, Moore ML, Goleniewska K, Hershey GK, Kolls JK, et al. A functional IL-13 receptor is expressed on polarized murine CD4+ Th17 cells and IL-13 signaling attenuates Th17 cytokine production. J Immunol. 2009;182(9):5317–21. PubMed PMID: 19380778.
Ranasinghe C, Ramshaw IA. Immunisation route-dependent expression of IL-4/IL-13 can modulate HIV-specific CD8(+) CTL avidity. Eur J Immunol. 2009;39(7):1819–30. PubMed PMID: 19582753.
Ranasinghe C, Turner SJ, McArthur C, Sutherland DB, Kim JH, Doherty PC, et al. Mucosal HIV-1 pox virus prime-boost immunization Induces high-avidity CD8+ T cells with regime-dependent cytokine/granzyme B profiles. J Immunol. 2007;178(4):2370–9. PubMed PMID: 17277143.
Ranasinghe C, Trivedi S, Stambas J, Jackson RJ. Unique IL-13Ralpha2-based HIV-1 vaccine strategy to enhance mucosal immunity, CD8(+) T-cell avidity and protective immunity. Mucosal Immunol. 2013;6(6):1068–80. PubMed PMID: 23403475.
Tabata Y, Khurana Hershey GK. IL-13 receptor isoforms: breaking through the complexity. Curr Allergy Asthma Rep. 2007;7(5):338–45. PubMed PMID: 17697639.
Trivedi S, Jackson RJ, Ranasinghe C. Different HIV pox viral vector-based vaccines and adjuvants can induce unique antigen presenting cells that modulate CD8 T cell avidity. Virology. 2014;468–470:479–89. PubMed PMID: 25261870.
Wijesundara DK, Tscharke DC, Jackson RJ, Ranasinghe C. Reduced interleukin-4 receptor alpha expression on CD8+ T cells correlates with higher quality antiviral immunity. PLoS One. 2013;8(1):e55788. PubMed PMID: 23383283.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG
About this entry
Cite this entry
Ranasinghe, C., Roy, S., Li, Z., Khanna, M., Jackson, R.J. (2018). IL-4 and IL-13 Receptors. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101978
Download citation
DOI: https://doi.org/10.1007/978-3-319-67199-4_101978
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-67198-7
Online ISBN: 978-3-319-67199-4
eBook Packages: Biomedical and Life SciencesReference Module Biomedical and Life Sciences