Skip to main content
SpringerLink
Log in

MSK1

  • Reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

  • 183 Accesses

Synonyms

90-kDa ribosomal protein S6 kinase 5; Mitogen- and stress-activated protein kinase 1; MSPK1; Nuclear mitogen- and stress-activated protein kinase-1; Ribosomal protein S6 kinase, 90kD, polypeptide 5; Ribosomal protein S6 kinase, polypeptide 5; RLPK; RLSK; Rps6ka5; Rsk-like (RSKL); Rsk-like protein kinase (RLPK)

Historical Background

Mitogen- and stress-activated protein kinase (Msk) 1 and Msk2 are nuclear serine/threonine kinases that are widely expressed in tissues including heart, brain, placenta, lung, liver, kidney, and pancreas, with the highest levels observed in brain, muscle, and placenta (Deak et al. 1998). They belong to a group of structurally related kinases called the AGC kinase (cAMP-dependent, cGMP-dependent, and protein kinase C) family. This group includes p70 ribosomal S6 kinase (S6 K), protein kinase B (PKB; also called Akt), protein kinase C-related kinase (Prk), p90 ribosomal S6 kinase (Rsk), and serum- and glucocorticoid-inducible kinase (Sgk) (Pearce et...

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 4,499.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 4,499.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Ananieva O, Darragh J, Johansen C, Carr JM, McIlrath J, Park JM, et al. The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling. Nat Immunol. 2008;9:1028–36.

    Article  CAS  PubMed  Google Scholar 

  • Arthur JS. MSK activation and physiological roles. Front Biosci. 2008;13:5866–79.

    Article  CAS  PubMed  Google Scholar 

  • Arthur JSC, Elcombe SE. MSK1 and MSK2 dependent regulation of immunity. In: Arthur JS, editor. MSKs. Austin: Landes Biosciences; 2014.

    Google Scholar 

  • Brami-Cherrier K, Valjent E, Hervé D, Darragh J, Corvol J, Pages C, Arthur SJ, Simon AJ, Girault JA, Caboche J. Parsing molecular and behavioral effects of cocaine in mitogen-and stress-activated protein kinase-1-deficient mice. J Neurosci. 2005;25:11444–54. https://doi.org/10.1523/JNEUROSCI.1711-05.2005.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Brami-Cherrier K, Lavaur J, Pagès C, Arthur SJC, Caboche J. Glutamate induces histone H3 phosphorylation but not acetylation in striatal neurons:Role of mitogen-and stress-activated kinase-1. J Neurochem. 2007;101:697–708. https://doi.org/10.1111/j.1471-4159.2006.04352.x.

    Article  CAS  PubMed  Google Scholar 

  • Brami-Cherrier K, Roze E, Girault JA, Betuing S, Caboche J. Role of the ERK/MSK1 signalling pathway in chromatin remodelling and brain responses to drugs of abuse. J Neurochem. 2009;108:1323–35.

    Article  CAS  PubMed  Google Scholar 

  • Chakraborty A, Diefenbacher ME, Mylona A, Kassel O, Behrens A. The E3 ubiquitin ligase Trim7 mediates c-Jun/AP-1 activation by Ras signalling. Nat Commun. 2015;6:6782. https://doi.org/10.1038/ncomms7782. PMID: 25851810.

    Article  PubMed  CAS  Google Scholar 

  • Chang S, Iversen L, Kragballe K, Arthur JSC, Johansen C. Mice lacking MSK1 and MSK2 show reduced skin tumor development in a two-stage chemical carcinogenesis model. Cancer Investig. 2011;29:240–5. https://doi.org/10.3109/07357907.2010.550594.

    Article  CAS  Google Scholar 

  • Clark CJ, McDade DM, O’Shaughnessy CT, Morris BJ. Contrasting roles of neuronal MSK1 and Rsk2 in Bad phosphorylation and feedback regulation of Erk signalling. J Neurochem. 2007;102:1024–34.

    Article  CAS  PubMed  Google Scholar 

  • Deak M, Clifton AD, Lucocq LM, Alessi DR. Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. EMBO J. 1998;17:4426–41.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Drobic B, Rerez-Cadahia B, Khan P, Healy S, Davie JR. Role of Mitogen and Stress activated kinases in Histone Phosphorylation. In: Arthur JS, editor. MSKs. Austin: Landes Biosciences; 2014.

    Google Scholar 

  • Duda K, Frödin M. Stimuli that activate MSK in cells and the molecular mechanism of activation. In: Arthur JS, editor. MSKs. Austin: Landes Biosciences; 2014.

    Google Scholar 

  • El Mchichi B, Hadji A, Vazquez A, Leca G. p38 MAPK and MSK1 mediate caspase-8 activation in manganese-induced mitochondria-dependent cell death. Cell Death Differ. 2007;14:1826–36.

    Article  CAS  PubMed  Google Scholar 

  • Elcombe S, Naqvi S, Van Den Bosch M, MacKenzie K, Cianfanelli F, Brown GD, Arthur JS. Dectin-1 regulates IL-10 production via a MSK1/2 and CREB dependent pathway and promotes the induction of regulatory macrophage markers. PLoS One. 2013;8:e60086. https://doi.org/10.1371/journal.pone.0060086.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Franguelli BG, Correa SAL. Regulation and role of MSK in the mammalian brain. In: Arthur JS, editor. MSKs. Austin: Landes Biosciences; 2014.

    Google Scholar 

  • Hughes JP, Staton PC, Wilkinson MG, Strijbos PJ, Skaper SD, Arthur JS, Reith AD. Mitogen and stress response kinase-1 (MSK1) mediates excitotoxic induced death of hippocampal neurones. J Neurochem. 2003;86:25–32.

    Article  CAS  PubMed  Google Scholar 

  • Kannan-Thulasiraman P, Katsoulidis E, Tallman MS, Arthur JS, Platanias LC. Activation of the mitogen- and stress-activated kinase 1 by arsenic trioxide. J Biol Chem. 2006;281:22446–52.

    Article  CAS  PubMed  Google Scholar 

  • Kim HG, Lee KW, Cho YY, Kang NJ, Oh SM, Bode AM, Dong Z. Mitogen- and stress-activated kinase 1-mediated histone H3 phosphorylation is crucial for cell transformation. Cancer Res. 2008;68:2538–47.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Lang E, Bissinger R, Fajol A, Salker MS, Singh Y, Zelenak C, Ghashghaeinia M, Gu S, Jilani K, Lupescu A, Reyskens KM, Ackermann TF, Föller M, Schleicher E, Sheffield WP, Arthur JS, Lang F, Qadri SM. Accelerated apoptotic death and in vivo turnover of erythrocytes in mice lacking functional mitogen- and stress-activated kinase MSK1/2. Sci Rep. 2015;5:17316. https://doi.org/10.1038/srep17316.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Lazou A, Markou T. MSK1. UCSD-nature molecule pages. 2010. https://doi.org/10.1038/mp.a001562.01.

  • Liu G, Zhang Y, Bode AM, Ma WY, Dong Z. Phosphorylation of 4E-BP1 is mediated by the p38/MSK1 pathway in response to UVB irradiation. J Biol Chem. 2002;277:8810–6.

    Article  CAS  PubMed  Google Scholar 

  • Markou T, Cieslak D, Gaitanaki C, Lazou A. Differential roles of MAPKs and MSK1 signalling pathways in the regulation of c-Jun during phenylephrine-induced cardiac myocyte hypertrophy. Mol Cell Biochem. 2009;322:1–2.

    Article  CAS  Google Scholar 

  • Martin E, Betuing S, Pagès C, Cambon K, Auregan G, Deglon N, Roze E, Caboche J. Mitogen-and stress-activated protein kinase1-induced neuroprotection in Huntington’s disease: role on chromatin remodeling at the PGC-1-alpha promoter. Hum Mol Genet. 2011;20:2422–34. https://doi.org/10.1093/hmg/ddr148.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • McCoy CE, Macdonald A, Morrice NA, Campbell DG, Deak M, Toth R, McIlrath J, Arthur JS. Identification of novel phosphorylation sites in MSK1 by precursor ion scanning MS. Biochem J. 2007;402:491–501.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Mellidis K, Dokalis N, Barlaka E, Lazou A. Activation of mitogen and stress activated kinase 1 (MSK1) during oxidative stress modulates apoptotic and autophagy pathways leading to cardioprotection. Cardiovasc Res. 2014;103(suppl 1):S14.

    Article  Google Scholar 

  • Naqvi S, Arthur JSC. The activation of CREB downstream of mitogen activated kinase (MAPK) signaling. In: Arthur JS, editor. MSKs. Austin: Landes Biosciences; 2014.

    Google Scholar 

  • Nomura M, Kaji A, Ma WY, Zhong S, Liu G, Bowden GT, Miyamoto KI, Dong Z. Mitogen- and stress-activated protein kinase 1 mediates activation of Akt by ultraviolet B irradiation. J Biol Chem. 2001;276:25558–67.

    Article  CAS  PubMed  Google Scholar 

  • Pearce LR, Komander D, Alessi DR. The nuts and bolts of AGC protein kinases. Nat Rev Mol Cell Biol. 2010;11:9–22.

    Article  CAS  PubMed  Google Scholar 

  • Reber LL, Haegeman G. The role of MSKs in regulating NF-κB activation. In: Arthur JS, editor. MSKs. Austin: Landes Biosciences; 2014.

    Google Scholar 

  • Reyskens KMSE, Arthur JSC. Emerging roles of mitogen activates kinases MSK1 and MSK2. Front Cell Dev Biol. 2016;4:56. https://doi.org/10.3389/fcell.2016.00056.

    Article  PubMed  PubMed Central  Google Scholar 

  • Roze E, Betuing S, Deyts C, Marcon E, Brami-Cherrier K, Pagès C, Humbert S, Mérienne K, Caboche J. Mitogen-and stress-activated protein kinase-1deficiency is involved in expanded-huntingtin-induced transcriptional dysregulation and striatal death. FASEB J. 2008;22:1083–93. https://doi.org/10.1096/fj.07-9814.

    Article  CAS  PubMed  Google Scholar 

  • Schiller M, Böhm M, Dennler S, Ehrchen JM, Mauviel A. Mitogen- and stress-activated protein kinase 1 is critical for interleukin-1-induced, CREB-mediated, c-fos gene expression in keratinocytes. Oncogene. 2006;25:4449–57.

    Article  CAS  PubMed  Google Scholar 

  • She QB, Ma WY, Zhong S, Dong Z. Activation of JNK1, RSK2, and MSK1 is involved in serine 112 phosphorylation of Bad by ultraviolet B radiation. J Biol Chem. 2002;277:24039–48.

    Article  CAS  PubMed  Google Scholar 

  • Shimada M, Nakadai T, Fukuda A, Hisatake K. cAMP-response element-binding protein (CREB) controls MSK1-mediated phosphorylation of histone H3 at the c-fos promoter in vitro. J Biol Chem. 2010;285:9390–401.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Thomson S, Clayton AL, Hazzalin CA, Rose S, Barratt MJ, Mahadevan LC. The nucleosomal response associated with immediate-early gene induction is mediated via alternative MAP kinase cascades: MSK1 as a potential histone H3/HMG-14 kinase. EMBO J. 1999;18:4779–93.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • van der Heide LP, van Dinther M, Moustakas A, ten Dijke P. TGFbeta activates mitogen- and stress-activated protein kinase-1 (MSK1) to attenuate cell death. J Biol Chem. 2011;286:5003–11.

    Article  CAS  PubMed  Google Scholar 

  • Vermeulen L, De Wilde G, Van Damme P, Vanden Berghe W, Haegeman G. Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1). EMBO J. 2003;22:1313–24.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Vermeulen L, Vanden Berghe W, Beck IM, De Bosscher K, Haegeman G. The versatile role of MSKs in transcriptional regulation. Trends Biochem Sci. 2009;34:311–8.

    Article  CAS  PubMed  Google Scholar 

  • Wierenga AT, Vogelzang I, Eggen BJ, Vellenga E. Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway. Exp Hematol. 2003;31:398–405.

    Article  CAS  PubMed  Google Scholar 

  • Wu S, Wang S, Zheng S, Verhaak R, Koul D, Yung WK. MSK1-mediated β-catenin phosphorylation confers resistance to PI3K/mTOR inhibitors in glioblastoma. Mol Biol Cell. 2016;15:1656–68.

    CAS  Google Scholar 

  • Zhang HM, Li L, Papadopoulou N, Hodgson G, Evans E, Galbraith M, et al. Mitogen-induced recruitment of ERK and MSK to SRE promoter complexes by ternary complex factor Elk-1. Nucleic Acids Res. 2008;36:2594–607.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. School of Biology, Aristotle University of Thessaloniki, Thessaloniki, 54124, Greece

    Antigone Lazou & Thomais Markou

Authors
  1. Antigone Lazou
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Thomais Markou
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Antigone Lazou .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Lazou, A., Markou, T. (2018). MSK1. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_604

Download citation

Publish with us

Policies and ethics

Search

Navigation