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Pancreatic Neuroendocrine Tumors

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Geriatric Gastroenterology

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Abstract

Neuroendocrine tumors (NETs) are a relatively rare and heterogeneous group, comprising about 2% of all malignancies with almost 2/3 of NETs being nonfunctional tumors. The incidence increases with age. Most non-appendix, non-pancreas NETs are seen in age over 60 years. Diagnosis of NET is often challenging and requires careful clinical history along with laboratory tests and an array of imaging procedures. While functioning NETs could present with symptoms related to hormone hypersecretion, non-functioning NETs often present incidentally or due to mass effect. Surgical resection remains the treatment of choice even with metastatic disease. The newer diagnostic and treatment modalities offer potential treatment and prolong disease-free survival for patients with improvement in quality of life.

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References

  • Akerstrom G, Hellman P. Surgery on neuroendocrine tumours. Best Pract Res Clin Endocrinol Metab. 2007;21:87–109.

    Article  PubMed  Google Scholar 

  • American Cancer Society. Pancreatic cancer survival by stage. http://www.cancer.org/Cancer/PancreaticCancer/DetailedGuide/pancreatic-cancer-survival-rates. 2012

  • Basu B, Sirohi B, Corrie P. Systemic therapy for neuroendocrine tumours of gastroenteropancreatic origin. Endocr Relat Cancer. 2010;17:R75–90.

    Article  CAS  PubMed  Google Scholar 

  • Bosman FT, Carneiro F, Hruban RH, Theise ND. Tumours of the pancreas. Lyon: IARC Press; 2010.

    Google Scholar 

  • Boukhman MP, et al. Localization of insulinomas. Arch Surg. 1999;134:818–22; discussion 822–813.

    Article  CAS  PubMed  Google Scholar 

  • Boyce M, Thomsen L. Gastric neuroendocrine tumors: prevalence in Europe, USA, and Japan, and rationale for treatment with a gastrin/CCK2 receptor antagonist. Scand J Gastroenterol. 2015;50:550–9.

    Article  CAS  PubMed  Google Scholar 

  • Brizi MG, et al. High resolution spiral computed tomography of the pancreas. Rays. 2001;26:111–5.

    CAS  PubMed  Google Scholar 

  • Cadiot G, et al. Preoperative detection of duodenal gastrinomas and peripancreatic lymph nodes by somatostatin receptor scintigraphy. Groupe D’etude Du Syndrome De Zollinger-Ellison. Gastroenterology. 1996;111:845–54.

    Article  CAS  PubMed  Google Scholar 

  • Campana D, et al. Chromogranin A: is it a useful marker of neuroendocrine tumors? J Clin Oncol. 2007;25:1967–73.

    Article  CAS  PubMed  Google Scholar 

  • Chamberlain RS, et al. Hepatic neuroendocrine metastases: does intervention alter outcomes? J Am Coll Surg. 2000;190:432–45.

    Article  CAS  PubMed  Google Scholar 

  • Chatzipantelis P, et al. Endoscopic ultrasound-guided fine-needle aspiration cytology of pancreatic neuroendocrine tumors: a study of 48 cases. Cancer. 2008;114:255–62.

    Article  PubMed  Google Scholar 

  • Corleto VD, Delle Fave G, Jensen RT. Molecular insights into gastrointestinal neuroendocrine tumours: importance and recent advances. Dig Liver Dis. 2002;34:668–80.

    Article  CAS  PubMed  Google Scholar 

  • Dabizzi E, Panossian A, Raimondo M. Management of pancreatic neuroendocrine tumors. Minerva Gastroenterol Dietol. 2010;56:467–79.

    CAS  PubMed  Google Scholar 

  • de Herder WW. Biochemistry of neuroendocrine tumours. Best Pract Res Clin Endocrinol Metab. 2007;21:33–41.

    Article  PubMed  CAS  Google Scholar 

  • Doppman JL, et al. Insulinomas: localization with selective intraarterial injection of calcium. Radiology. 1991;178:237–41.

    Article  CAS  PubMed  Google Scholar 

  • Doppman JL, et al. Localization of insulinomas to regions of the pancreas by intra-arterial stimulation with calcium. Ann Intern Med. 1995;123:269–73.

    Article  CAS  PubMed  Google Scholar 

  • Dromain C, et al. Detection of liver metastases from endocrine tumors: a prospective comparison of somatostatin receptor scintigraphy, computed tomography, and magnetic resonance imaging. J Clin Oncol. 2005;23:70–8.

    Article  PubMed  Google Scholar 

  • Duerr EM, Chung DC. Molecular genetics of neuroendocrine tumors. Best Pract Res Clin Endocrinol Metab. 2007;21:1–14.

    Article  CAS  PubMed  Google Scholar 

  • Duran I, et al. A phase II clinical and pharmacodynamic study of temsirolimus in advanced neuroendocrine carcinomas. Br J Cancer. 2006;95:1148–54.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Edge SB, Compton CC. The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol. 2010;17:1471–4.

    Article  PubMed  Google Scholar 

  • Falconi M, et al. Well-differentiated pancreatic nonfunctioning tumors/carcinoma. Neuroendocrinology. 2006;84:196–211.

    Article  CAS  PubMed  Google Scholar 

  • Fendrich V, Waldmann J, Bartsch DK, Langer P. Surgical management of pancreatic endocrine tumors. Nat Rev Clin Oncol. 2009;6:419–28.

    Article  PubMed  Google Scholar 

  • Fidler JL, Johnson CD. Imaging of neuroendocrine tumors of the pancreas. Int J Gastrointest Cancer. 2001;30:73–85.

    Article  CAS  PubMed  Google Scholar 

  • Fink G, et al. Pulmonary carcinoid: presentation, diagnosis, and outcome in 142 cases in Israel and review of 640 cases from the literature. Chest. 2001;119:1647–51.

    Article  CAS  PubMed  Google Scholar 

  • Forrer F, Valkema R, Kwekkeboom DJ, de Jong M, Krenning EP. Neuroendocrine tumors. Peptide receptor radionuclide therapy. Best Pract Res Clin Endocrinol Metab. 2007;21:111–29.

    Article  CAS  PubMed  Google Scholar 

  • Fottner C, et al. In vivo molecular imaging of somatostatin receptors in pancreatic islet cells and neuroendocrine tumors by miniaturized confocal laser-scanning fluorescence microscopy. Endocrinology. 2010;151:2179–88.

    Article  CAS  PubMed  Google Scholar 

  • Frucht H, et al. Detection of duodenal gastrinomas by operative endoscopic transillumination. A prospective study. Gastroenterology. 1990;99:1622–7.

    Article  CAS  PubMed  Google Scholar 

  • Gibril F, Jensen RT. Zollinger-Ellison syndrome revisited: diagnosis, biologic markers, associated inherited disorders, and acid hypersecretion. Curr Gastroenterol Rep. 2004;6:454–63.

    Article  PubMed  Google Scholar 

  • Gibril F, Venzon DJ, Ojeaburu JV, Bashir S, Jensen RT. Prospective study of the natural history of gastrinoma in patients with MEN1: definition of an aggressive and a nonaggressive form. J Clin Endocrinol Metab. 2001;86:5282–93.

    Article  CAS  PubMed  Google Scholar 

  • Gill GV, Rauf O, MacFarlane IA. Diazoxide treatment for insulinoma: a national UK survey. Postgrad Med J. 1997;73:640–1.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Goetz M, Kiesslich R. Advances of endomicroscopy for gastrointestinal physiology and diseases. Am J Physiol Gastrointest Liver Physiol. 2010;298:G797–806.

    Article  CAS  PubMed  Google Scholar 

  • Goudet P, et al. Risk factors and causes of death in MEN1 disease. A GTE (Groupe d’Etude des Tumeurs Endocrines) cohort study among 758 patients. World J Surg. 2010;34:249–55.

    Article  PubMed  Google Scholar 

  • Grant CS. Surgical management of malignant islet cell tumors. World J Surg. 1993;17:498–503.

    Article  CAS  PubMed  Google Scholar 

  • Grant CS. Insulinoma. Best Pract Res Clin Gastroenterol. 2005;19:783–98.

    Article  CAS  PubMed  Google Scholar 

  • Gray’s anatomy: the anatomical basis of clinical practice. (ed. DSc, S.S.P.) 1562 (Elsevier, 2015).

    Google Scholar 

  • Gregoire E, Le Treut YP. Liver transplantation for primary or secondary endocrine tumors. Transpl Int. 2010;23:704–11.

    Article  PubMed  Google Scholar 

  • Halperin DM, Kulke MH. Management of pancreatic neuroendocrine tumors. Gastroenterol Clin N Am. 2012;41:119–31.

    Article  Google Scholar 

  • Hellman P, et al. Surgical strategy for large or malignant endocrine pancreatic tumors. World J Surg. 2000;24:1353–60.

    Article  CAS  PubMed  Google Scholar 

  • Hellman P, Hennings J, Akerstrom G, Skogseid B. Endoscopic ultrasonography for evaluation of pancreatic tumours in multiple endocrine neoplasia type 1. Br J Surg. 2005;92:1508–12.

    Article  CAS  PubMed  Google Scholar 

  • Hill JS, et al. Pancreatic neuroendocrine tumors: the impact of surgical resection on survival. Cancer. 2009;115:741–51.

    Article  PubMed  Google Scholar 

  • Hirshberg B, et al. Blind distal pancreatectomy for occult insulinoma, an inadvisable procedure. J Am Coll Surg. 2002;194:761–4.

    Article  PubMed  Google Scholar 

  • Hobday TJ, Rubin J, Holen K, Picus J, Donehower R, Marschke R, Maples W, Lloyd R, Mahoney M, Erlichman C. MC044h, a phase II trial of sorafenib in patients (pts) with metastatic neuroendocrine tumors (NET): a Phase II Consortium (P2C) study. In: 2007 ASCO annual meeting proceedings, vol. 25, p. 4504. J Clin Oncol, 2007.

    Article  Google Scholar 

  • Huai JC, et al. Localization and surgical treatment of pancreatic insulinomas guided by intraoperative ultrasound. Am J Surg. 1998;175:18–21.

    Article  CAS  PubMed  Google Scholar 

  • Imamura M, et al. New pancreas-preserving total duodenectomy technique. World J Surg. 2005;29:203–7.

    Article  PubMed  Google Scholar 

  • Imamura M, Komoto I, Ota S. Changing treatment strategy for gastrinoma in patients with Zollinger-Ellison syndrome. World J Surg. 2006;30:1–11.

    Article  PubMed  Google Scholar 

  • Ito H, et al. Surgery and staging of pancreatic neuroendocrine tumors: a 14-year experience. J Gastrointest Surg. 2010;14:891–8.

    Article  PubMed  Google Scholar 

  • Jameson JL, Fauci AS, Kasper DL, Hauser SL, Longo DL, Loscalzo J. Harrison’s principles of internal medicine. United States of America: The McGraw-Hill Companies; 2012.

    Google Scholar 

  • Jensen RT, et al. Gastrinoma (duodenal and pancreatic). Neuroendocrinology. 2006;84:173–82.

    Article  CAS  PubMed  Google Scholar 

  • Jensen RT, Berna MJ, Bingham DB, Norton JA. Inherited pancreatic endocrine tumor syndromes: advances in molecular pathogenesis, diagnosis, management, and controversies. Cancer. 2008;113:1807–43.

    Article  PubMed  Google Scholar 

  • Kaltsas GA, Besser GM, Grossman AB. The diagnosis and medical management of advanced neuroendocrine tumors. Endocr Rev. 2004;25:458–511.

    Article  CAS  PubMed  Google Scholar 

  • Kato M, et al. Curative resection of microgastrinomas based on the intraoperative secretin test. World J Surg. 2000;24:1425–30.

    Article  CAS  PubMed  Google Scholar 

  • King CM, Reznek RH, Dacie JE, Wass JA. Imaging islet cell tumours. Clin Radiol. 1994;49:295–303.

    Article  PubMed  Google Scholar 

  • Klimstra DS. Nonductal neoplasms of the pancreas. Mod Pathol. 2007;20(Suppl 1):S94–112.

    Article  PubMed  Google Scholar 

  • Klimstra DS, et al. Pathology reporting of neuroendocrine tumors: application of the Delphic consensus process to the development of a minimum pathology data set. Am J Surg Pathol. 2010;34:300–13.

    Article  PubMed  Google Scholar 

  • Kloppel G, Perren A, Heitz PU. The gastroenteropancreatic neuroendocrine cell system and its tumors: the WHO classification. Ann N Y Acad Sci. 2004;1014:13–27.

    Article  PubMed  Google Scholar 

  • Konda VJ, et al. First assessment of needle-based confocal laser endomicroscopy during EUS-FNA procedures of the pancreas (with videos). Gastrointest Endosc. 2011;74:1049–60.

    Article  PubMed  Google Scholar 

  • Kouvaraki MA, et al. Management of pancreatic endocrine tumors in multiple endocrine neoplasia type 1. World J Surg. 2006;30:643–53.

    Article  PubMed  Google Scholar 

  • Krausz Y, et al. SPECT/CT hybrid imaging with 111In-pentetreotide in assessment of neuroendocrine tumours. Clin Endocrinol. 2003;59:565–73.

    Article  Google Scholar 

  • Krenning EP, et al. Somatostatin receptor scintigraphy with [111In-DTPA-D-Phe1]- and [123I-Tyr3]-octreotide: the Rotterdam experience with more than 1000 patients. Eur J Nucl Med. 1993;20:716–31.

    Article  CAS  PubMed  Google Scholar 

  • Kulke MH, et al. NANETS treatment guidelines: well-differentiated neuroendocrine tumors of the stomach and pancreas. Pancreas. 2010;39:735–52.

    Article  PubMed  PubMed Central  Google Scholar 

  • Kulke MH, et al. Future directions in the treatment of neuroendocrine tumors: consensus report of the National Cancer Institute Neuroendocrine Tumor clinical trials planning meeting. J Clin Oncol. 2011;29:934–43.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kwekkeboom DJ, et al. Treatment with the radiolabeled somatostatin analog [177 Lu-DOTA 0,Tyr3]octreotate: toxicity, efficacy, and survival. J Clin Oncol. 2008;26:2124–30.

    Article  CAS  PubMed  Google Scholar 

  • Lamberts SW, Bakker WH, Reubi JC, Krenning EP. Somatostatin-receptor imaging in the localization of endocrine tumors. N Engl J Med. 1990;323:1246–9.

    Article  CAS  PubMed  Google Scholar 

  • Langer P, et al. Prospective evaluation of imaging procedures for the detection of pancreaticoduodenal endocrine tumors in patients with multiple endocrine neoplasia type 1. World J Surg. 2004;28:1317–22.

    Article  PubMed  Google Scholar 

  • Lawrence B, et al. The epidemiology of gastroenteropancreatic neuroendocrine tumors. Endocrinol Metab Clin N Am. 2011;40:1–18. , vii.

    Article  Google Scholar 

  • Le Treut YP, et al. Predictors of long-term survival after liver transplantation for metastatic endocrine tumors: an 85-case French multicentric report. Am J Transplant. 2008;8:1205–13.

    Article  PubMed  Google Scholar 

  • Legmann P, et al. Pancreatic tumors: comparison of dual-phase helical CT and endoscopic sonography. AJR Am J Roentgenol. 1998;170:1315–22.

    Article  CAS  PubMed  Google Scholar 

  • Liszka L, et al. Discrepancies between two alternative staging systems (European Neuroendocrine Tumor Society 2006 and American Joint Committee on Cancer/Union for International Cancer Control 2010) of neuroendocrine neoplasms of the pancreas. A study of 50 cases. Pathol Res Pract. 2011;207:220–4.

    Article  PubMed  Google Scholar 

  • Mertz H, Gautam S. The learning curve for EUS-guided FNA of pancreatic cancer. Gastrointest Endosc. 2004;59:33–7.

    Article  PubMed  Google Scholar 

  • Metz DC, Jensen RT. Gastrointestinal neuroendocrine tumors: pancreatic endocrine tumors. Gastroenterology. 2008;135:1469–92.

    Article  CAS  PubMed  Google Scholar 

  • Miederer M, Weber MM, Fottner C. Molecular imaging of gastroenteropancreatic neuroendocrine tumors. Gastroenterol Clin N Am. 2010;39:923–35.

    Article  Google Scholar 

  • Minter RM, Simeone DM. Contemporary management of nonfunctioning pancreatic neuroendocrine tumors. J Gastrointest Surg. 2012;16:435–46.

    Article  PubMed  Google Scholar 

  • Modlin IM, Cornelius E, Lawton GP. Use of an isotopic somatostatin receptor probe to image gut endocrine tumors. Arch Surg. 1995;130:367–73; discussion 373–364.

    Article  CAS  PubMed  Google Scholar 

  • Modlin IM, et al. Gastroenteropancreatic neuroendocrine tumours. Lancet Oncol. 2008;9:61–72.

    Article  CAS  PubMed  Google Scholar 

  • Moertel CG, Lefkopoulo M, Lipsitz S, Hahn RG, Klaassen D. Streptozocin-doxorubicin, streptozocin-fluorouracil or chlorozotocin in the treatment of advanced islet-cell carcinoma. N Engl J Med. 1992;326:519–23.

    Article  CAS  PubMed  Google Scholar 

  • Muniraj T, Vignesh S, Shetty S, Thiruvengadam S, Aslanian HR. Pancreatic neuroendocrine tumors. Dis Mon. 2013;59:5–19.

    Article  PubMed  Google Scholar 

  • Norton JA. Surgery for primary pancreatic neuroendocrine tumors. J Gastrointest Surg. 2006;10:327–31.

    Article  PubMed  Google Scholar 

  • Norton JA, et al. Morbidity and mortality of aggressive resection in patients with advanced neuroendocrine tumors. Arch Surg. 2003;138:859–66.

    Article  PubMed  Google Scholar 

  • Norton JA, et al. Surgery increases survival in patients with gastrinoma. Ann Surg. 2006;244:410–9.

    PubMed  PubMed Central  Google Scholar 

  • O’Grady HL, Conlon KC. Pancreatic neuroendocrine tumours. Eur J Surg Oncol. 2008;34:324–32.

    Article  PubMed  Google Scholar 

  • Oronsky B, Ma PC, Morgensztern D, Carter CA. Nothing but NET: a review of neuroendocrine tumors and carcinomas. Neoplasia (New York, NY). 2017;19:991–1002.

    Article  CAS  Google Scholar 

  • Pape UF, et al. Prognostic relevance of a novel TNM classification system for upper gastroenteropancreatic neuroendocrine tumors. Cancer. 2008;113:256–65.

    Article  PubMed  Google Scholar 

  • Phan AT, Yao JC, Fogelman DR, Hess KR, Ng CS, Bullock SA, Malinowski P, Regan E, Kulke M. A prospective, multi-institutional phase II study of GW786034 (pazopanib) and depot octreotide (sandostatin LAR) in advanced low-grade neuroendocrine carcinoma (LGNEC). In: ASCO annual meeting, vol. 28, p. 4001. J Clin Oncol 2010).

    Article  Google Scholar 

  • Plockinger U, et al. Guidelines for the diagnosis and treatment of neuroendocrine gastrointestinal tumours. A consensus statement on behalf of the European Neuroendocrine Tumour Society (ENETS). Neuroendocrinology. 2004;80:394–424.

    Article  CAS  PubMed  Google Scholar 

  • Raymond E, et al. Sunitinib malate for the treatment of pancreatic neuroendocrine tumors. N Engl J Med. 2011;364:501–13.

    Article  CAS  PubMed  Google Scholar 

  • Rindi G, et al. TNM staging of foregut (neuro)endocrine tumors: a consensus proposal including a grading system. Virchows Arch. 2006;449:395–401.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rosch T, et al. Localization of pancreatic endocrine tumors by endoscopic ultrasonography. N Engl J Med. 1992;326:1721–6.

    Article  CAS  PubMed  Google Scholar 

  • Roy PK, et al. Zollinger-Ellison syndrome. Clinical presentation in 261 patients. Medicine (Baltimore). 2000;79:379–411.

    Article  CAS  Google Scholar 

  • Saadettin Kilickap HKM. Neuroendocrine tumours diagnosis and management. New York: Springer; 2015.

    Google Scholar 

  • Sakurai A, et al. Long-term follow-up of patients with multiple endocrine neoplasia type 1. Endocr J. 2007;54:295–302.

    Article  PubMed  Google Scholar 

  • Sarmiento JM, Que FG. Hepatic surgery for metastases from neuroendocrine tumors. Surg Oncol Clin N Am. 2003;12:231–42.

    Article  PubMed  Google Scholar 

  • Scarpa A, et al. Pancreatic endocrine tumors: improved TNM staging and histopathological grading permit a clinically efficient prognostic stratification of patients. Mod Pathol. 2010;23:824–33.

    Article  CAS  PubMed  Google Scholar 

  • Schillaci O, Corleto VD, Annibale B, Scopinaro F, Delle Fave G. Single photon emission computed tomography procedure improves accuracy of somatostatin receptor scintigraphy in gastro-entero pancreatic tumours. Ital J Gastroenterol Hepatol. 1999;31(Suppl 2):S186–9.

    PubMed  Google Scholar 

  • Schott M, et al. Neuroendocrine neoplasms of the gastrointestinal tract. Dtsch Arztebl Int. 2011;108:305–12.

    PubMed  PubMed Central  Google Scholar 

  • Schottelius M, et al. First (18)F-labeled tracer suitable for routine clinical imaging of sst receptor-expressing tumors using positron emission tomography. Clin Cancer Res. 2004;10:3593–606.

    Article  CAS  PubMed  Google Scholar 

  • Strosberg J, Nasir A, Coppola D, Wick M, Kvols L. Correlation between grade and prognosis in metastatic gastroenteropancreatic neuroendocrine tumors. Hum Pathol. 2009;40:1262–8.

    Article  PubMed  Google Scholar 

  • Strosberg JR, et al. Prognostic validity of a novel American Joint Committee on Cancer Staging Classification for pancreatic neuroendocrine tumors. J Clin Oncol. 2011a;29:3044–9.

    Article  PubMed  Google Scholar 

  • Strosberg JR, et al. First-line chemotherapy with capecitabine and temozolomide in patients with metastatic pancreatic endocrine carcinomas. Cancer. 2011b;117:268–75.

    Article  CAS  PubMed  Google Scholar 

  • Thom AK, et al. Prospective study of the use of intraarterial secretin injection and portal venous sampling to localize duodenal gastrinomas. Surgery. 1992;112:1002–8; discussion 1008–1009.

    CAS  PubMed  Google Scholar 

  • Thomas-Marques L, et al. Prospective endoscopic ultrasonographic evaluation of the frequency of nonfunctioning pancreaticoduodenal endocrine tumors in patients with multiple endocrine neoplasia type 1. Am J Gastroenterol. 2006;101:266–73.

    Article  PubMed  Google Scholar 

  • Thompson NW, Eckhauser FE. Malignant islet-cell tumors of the pancreas. World J Surg. 1984;8:940–51.

    Article  CAS  PubMed  Google Scholar 

  • Thompson GB, van Heerden JA, Grant CS, Carney JA, Ilstrup DM. Islet cell carcinomas of the pancreas: a twenty-year experience. Surgery. 1988;104:1011–7.

    CAS  PubMed  Google Scholar 

  • Toumpanakis C, Meyer T, Caplin ME. Cytotoxic treatment including embolization/chemoembolization for neuroendocrine tumours. Best Pract Res Clin Endocrinol Metab. 2007;21:131–44.

    Article  CAS  PubMed  Google Scholar 

  • Touzios JG, et al. Neuroendocrine hepatic metastases: does aggressive management improve survival? Ann Surg. 2005;241:776–83; discussion 783–775.

    Article  PubMed  PubMed Central  Google Scholar 

  • Triponez F, et al. Is surgery beneficial for MEN1 patients with small (< or = 2 cm), nonfunctioning pancreaticoduodenal endocrine tumor? An analysis of 65 patients from the GTE. World J Surg. 2006;30:654–62; discussion 663–654.

    Article  PubMed  Google Scholar 

  • Vagefi PA, et al. Evolving patterns in the detection and outcomes of pancreatic neuroendocrine neoplasms: the Massachusetts General Hospital experience from 1977 to 2005. Arch Surg. 2007;142:347–54.

    Article  PubMed  PubMed Central  Google Scholar 

  • Van Hoe L, Gryspeerdt S, Marchal G, Baert AL, Mertens L. Helical CT for the preoperative localization of islet cell tumors of the pancreas: value of arterial and parenchymal phase images. AJR Am J Roentgenol. 1995;165:1437–9.

    Article  PubMed  Google Scholar 

  • Wamsteker EJ, Gauger PG, Thompson NW, Scheiman JM. EUS detection of pancreatic endocrine tumors in asymptomatic patients with type 1 multiple endocrine neoplasia. Gastrointest Endosc. 2003;58:531–5.

    Article  PubMed  Google Scholar 

  • Wang SC, et al. Identification of unknown primary tumors in patients with neuroendocrine liver metastases. Arch Surg. 2010;145:276–80.

    Article  PubMed  Google Scholar 

  • Wolf P, et al. Clinical presentation in insulinoma predicts histopathological tumour characteristics. Clin Endocrinol. 2015;83:67–71.

    Article  CAS  Google Scholar 

  • Yang RH, Chu YK. Zollinger-Ellison syndrome: revelation of the gastrinoma triangle. Radiol Case Rep. 2015;10:827.

    Article  PubMed  PubMed Central  Google Scholar 

  • Yao JC, et al. Population-based study of islet cell carcinoma. Ann Surg Oncol. 2007;14:3492–500.

    Article  PubMed  PubMed Central  Google Scholar 

  • Yao JC, et al. Daily oral everolimus activity in patients with metastatic pancreatic neuroendocrine tumors after failure of cytotoxic chemotherapy: a phase II trial. J Clin Oncol. 2010;28:69–76.

    Article  CAS  PubMed  Google Scholar 

  • Yao JC, et al. Everolimus for advanced pancreatic neuroendocrine tumors. N Engl J Med. 2011;364:514–23.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zatelli MC, et al. Chromogranin A as a marker of neuroendocrine neoplasia: an Italian Multicenter Study. Endocr Relat Cancer. 2007;14:473–82.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Yale University School of Medicine, New Haven, CT, USA

    Thiruvengadam Muniraj & Harry R. Aslanian

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  1. Thiruvengadam Muniraj
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  2. Harry R. Aslanian
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Correspondence to Thiruvengadam Muniraj .

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  1. Saint Peter's Healthcare System, New Brunswick, NJ, USA

    C. S. Pitchumoni

  2. Albert Einstein College of Medicine, Montefiore Medical Center, Wakefield Campus, Bronx, NY, USA

    T.S. Dharmarajan

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Muniraj, T., Aslanian, H.R. (2020). Pancreatic Neuroendocrine Tumors. In: Pitchumoni, C., Dharmarajan, T. (eds) Geriatric Gastroenterology. Springer, Cham. https://doi.org/10.1007/978-3-319-90761-1_81-1

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