Synonyms
Acute myelogenous leukemia; Acute nonlymphocytic leukemia; Agranular CD4+ CD56+ hematodermic neoplasm; Agranular CD4+ NK cell leukemia; Blastic NK cell lymphoma; Blastic NK leukemia/lymphoma
Definition
Acute Myeloid Leukemia (AML) is a bone marrow cancer, characterized by the clonal expansion and lack of differentiation of early myeloid cells. In the majority of cases, the diagnosis of AML requires a myeloid blast count ≥20% of nucleated cells in the blood or bone marrow. Blasts can also infiltrate other organs or tissues such as skin, gums, or lymph nodes. Rarely AML can present as an isolated myeloid sarcoma in any tissue. The definition of myeloid blasts includes abnormal promyelocytes in acute promyelocytic leukemia (APL), and promonocytes in monocytic/monoblastic AML. Almost any myeloid lineage can be affected; myeloid or monocytic are relatively common, but rare basophilic, pure erythroid and megakaryocytic forms of AML exist.
Classification
AML is an extremely...
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References and Further Reading
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Mitchell, E., Gudgin, E., Raso-Barnett, L. (2020). Acute Myeloid Leukemia and Related Neoplasms. In: Molina, T.J. (eds) Hematopathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-95309-0_3816
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DOI: https://doi.org/10.1007/978-3-319-95309-0_3816
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