Abstract
This chapter provides an overview of the basic principles of compartmental modeling as it is being applied to the quantitative analysis of positron emission tomography (PET) studies. Measurement of blood flow (perfusion) is used as an example of a single tissue compartment model and receptor studies are discussed in relation to a two tissue compartment model. Emphasis is placed on the accurate measurement of both arterial whole blood and metabolite-corrected plasma input functions. Reference tissue models are introduced as a noninvasive tool to investigate neuroreceptor studies. Finally, parametric methods are introduced in which calculations are performed at a voxel level.
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Lammertsma, A.A. (2012). Compartmental Modeling in Emission Tomography. In: Grupen, C., Buvat, I. (eds) Handbook of Particle Detection and Imaging. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-13271-1_42
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DOI: https://doi.org/10.1007/978-3-642-13271-1_42
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