Definition
Secondary open-angle glaucoma associated with PDS, an autosomal dominant disorder, in which irido-zonular friction disrupts the iris pigment epithelium dispersing pigment granules throughout the anterior chamber.
Etiology
The underlying condition, PDS, can be explained by the anatomical phenomenon of posterior iris concavity, caused by reverse pupillary block due to increased irido-lenticular contact and physiological events such as blinking and exercise. Increased aqueous pressure in the anterior chamber promotes a backward bowing of the iris and mechanical rubbing against the zonular fibers of the lens leading to liberation of iris pigment. PDS is believed to be strongly influenced by genetic background with linkage to chromosomal locations 7q35-36 and 18q22.
Clinical Presentation
PDS is a bilateral disorder. Key features are the dispersion and accumulation of pigment on anterior segment structures such as...
References
Anderson MG (2010) Pigmentary dispersion syndrome and glaucoma. In: Levin LA, Albert DM (eds) Ocular disease: mechanisms and management. Elsevier, Amsterdam, pp 165–170
Niyadurupola N, Broadway DC (2008) Pigment dispersion syndrome and pigmentary glaucoma – a major review. Clin Exp Ophthalmol 36:868–882
Ritch R (2010) Pigment dispersion syndrome and pigmentary glaucoma. In: Dartt DA, Besharse JC, Dana R (eds) Encyclopedia of the eye, vol 3. Academic, Oxford, pp 451–460
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Schlötzer-Schrehardt, U. (2016). Pigmentary Glaucoma. In: Schmidt-Erfurth, U., Kohnen, T. (eds) Encyclopedia of Ophthalmology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-35951-4_301-3
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DOI: https://doi.org/10.1007/978-3-642-35951-4_301-3
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Publisher Name: Springer, Berlin, Heidelberg
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